Gene description for Parva
Gene name parvin, alpha
Gene symbol Parva
Other names/aliases Actp
Species Rattus norvegicus
 Database cross references - Parva
ExoCarta ExoCarta_57341
Entrez Gene 57341
UniProt Q9HB97  
 Parva identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Parva
Molecular Function
    protein domain specific binding GO:0019904 IC
    actin binding GO:0003779 ISO
Biological Process
    heterotypic cell-cell adhesion GO:0034113 ISS
    protein heterooligomerization GO:0051291 IPI
    actin cytoskeleton organization GO:0030036 IDA
    smooth muscle cell chemotaxis GO:0071670 ISS
    cell adhesion GO:0007155 ISO
    outflow tract septum morphogenesis GO:0003148 ISS
    substrate adhesion-dependent cell spreading GO:0034446 ISS
    sprouting angiogenesis GO:0002040 ISS
    cilium morphogenesis GO:0060271 ISS
    actin-mediated cell contraction GO:0070252 ISS
    regulation of cell shape GO:0008360 IEA
    establishment or maintenance of cell polarity GO:0007163 ISS
    actin cytoskeleton reorganization GO:0031532 IEA
Subcellular Localization
    lamellipodium GO:0030027 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 IEA
    actin cytoskeleton GO:0015629 ISO
    protein complex GO:0043234 IDA
    Z disc GO:0030018 IEA
    focal adhesion GO:0005925 NAS
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified Parva in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Parva
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Parva is involved
No pathways found





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