Gene description for Parva
Gene name parvin, alpha
Gene symbol Parva
Other names/aliases Actp
Species Rattus norvegicus
 Database cross references - Parva
ExoCarta ExoCarta_57341
Vesiclepedia VP_57341
Entrez Gene 57341
UniProt Q9HB97  
 Parva identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Parva
Molecular Function
    actin binding GO:0003779 IBA
    actin binding GO:0003779 IEA
    actin binding GO:0003779 ISO
    protein kinase inhibitor activity GO:0004860 IEA
    protein kinase inhibitor activity GO:0004860 ISO
    protein kinase inhibitor activity GO:0004860 ISS
    protein domain specific binding GO:0019904 IC
    protein-containing complex binding GO:0044877 IDA
    protein-containing complex binding GO:0044877 IPI
Biological Process
    sprouting angiogenesis GO:0002040 IEA
    sprouting angiogenesis GO:0002040 ISO
    sprouting angiogenesis GO:0002040 ISS
    outflow tract septum morphogenesis GO:0003148 IEA
    outflow tract septum morphogenesis GO:0003148 ISO
    outflow tract septum morphogenesis GO:0003148 ISS
    cell adhesion GO:0007155 IEA
    cell adhesion GO:0007155 ISO
    establishment or maintenance of cell polarity GO:0007163 IEA
    establishment or maintenance of cell polarity GO:0007163 ISO
    establishment or maintenance of cell polarity GO:0007163 ISS
    actin cytoskeleton organization GO:0030036 IBA
    actin cytoskeleton organization GO:0030036 IDA
    actin cytoskeleton organization GO:0030036 IEA
    heterotypic cell-cell adhesion GO:0034113 IEA
    heterotypic cell-cell adhesion GO:0034113 ISO
    heterotypic cell-cell adhesion GO:0034113 ISS
    substrate adhesion-dependent cell spreading GO:0034446 IBA
    substrate adhesion-dependent cell spreading GO:0034446 IEA
    substrate adhesion-dependent cell spreading GO:0034446 ISO
    substrate adhesion-dependent cell spreading GO:0034446 ISS
    cilium assembly GO:0060271 IBA
    cilium assembly GO:0060271 IEA
    cilium assembly GO:0060271 ISO
    cilium assembly GO:0060271 ISS
    actin-mediated cell contraction GO:0070252 IEA
    actin-mediated cell contraction GO:0070252 ISO
    actin-mediated cell contraction GO:0070252 ISS
    smooth muscle cell chemotaxis GO:0071670 IEA
    smooth muscle cell chemotaxis GO:0071670 ISO
    smooth muscle cell chemotaxis GO:0071670 ISS
    establishment or maintenance of cell polarity regulating cell shape GO:0071963 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IEA
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 IEA
    focal adhesion GO:0005925 ISO
    focal adhesion GO:0005925 ISS
    focal adhesion GO:0005925 NAS
    actin cytoskeleton GO:0015629 IBA
    actin cytoskeleton GO:0015629 IEA
    actin cytoskeleton GO:0015629 ISO
    Z disc GO:0030018 IEA
    lamellipodium GO:0030027 IEA
    lamellipodium GO:0030027 ISO
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified Parva in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Parva
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here