Gene description for Gabarapl1
Gene name gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
Gene symbol Gabarapl1
Other names/aliases 3110025G09Rik
9130422N19Rik
AI196471
Apg8l
Atg8l
GECI
MNCb-0091
Species Mus musculus
 Database cross references - Gabarapl1
ExoCarta ExoCarta_57436
Vesiclepedia VP_57436
Entrez Gene 57436
UniProt Q8R3R8  
 Gabarapl1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Gabarapl1
Molecular Function
    protein binding GO:0005515 IPI
    phospholipid binding GO:0005543 IEA
    phospholipid binding GO:0005543 ISO
    cytoskeletal protein binding GO:0008092 ISA
    phosphatidylethanolamine binding GO:0008429 IBA
    Tat protein binding GO:0030957 IEA
    Tat protein binding GO:0030957 ISO
    ubiquitin protein ligase binding GO:0031625 IBA
    ubiquitin protein ligase binding GO:0031625 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    protein-membrane adaptor activity GO:0043495 ISO
    GABA receptor binding GO:0050811 IBA
Biological Process
    autophagosome assembly GO:0000045 IBA
    mitophagy GO:0000423 IBA
    cellular response to nitrogen starvation GO:0006995 IBA
    glycophagy GO:0061723 IMP
    substrate localization to autophagosome GO:0061753 ISO
    autophagosome maturation GO:0097352 IBA
Subcellular Localization
    autophagosome membrane GO:0000421 IBA
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
    autophagosome GO:0005776 ISO
    endoplasmic reticulum GO:0005783 IEA
    Golgi apparatus GO:0005794 IEA
    microtubule GO:0005874 IEA
    cytoplasmic vesicle membrane GO:0030659 IEA
    dendrite membrane GO:0032590 ISO
    dendrite cytoplasm GO:0032839 ISO
    cell body GO:0044297 ISO
 Experiment description of studies that identified Gabarapl1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Gabarapl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rnf123  
Co-fractionation Mus musculus
2 Dvl2  
Two-hybrid Mus musculus
3 Selo  
Co-fractionation Mus musculus
4 Atg5  
Affinity Capture-MS Mus musculus
Co-fractionation Mus musculus
5 Fnbp1  
Co-fractionation Mus musculus
6 Atg16l1  
Co-fractionation Mus musculus
7 MAPK15  
Two-hybrid Homo sapiens
8 Wdr11  
Co-fractionation Mus musculus
9 Fyco1  
Co-fractionation Mus musculus
10 Gabarap  
Co-fractionation Mus musculus
11 Nipsnap1  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Gabarapl1 is involved
PathwayEvidenceSource
Autophagy IEA Reactome
Macroautophagy IEA Reactome





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