Gene description for TENM2
Gene name teneurin transmembrane protein 2
Gene symbol TENM2
Other names/aliases ODZ2
TEN-M2
TNM2
Species Homo sapiens
 Database cross references - TENM2
ExoCarta ExoCarta_57451
Vesiclepedia VP_57451
Entrez Gene 57451
HGNC 29943
MIM 610119
 TENM2 identified in exosomes derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for TENM2
Molecular Function
    protein homodimerization activity GO:0042803 ISS
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 ISS
    receptor binding GO:0005102 IEA
    cell adhesion molecule binding GO:0050839 IDA
Biological Process
    axon guidance GO:0007411 IDA
    signal transduction GO:0007165 IEA
    self proteolysis GO:0097264 IEA
    positive regulation of filopodium assembly GO:0051491 ISS
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IDA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    single organismal cell-cell adhesion GO:0016337 ISS
    calcium-mediated signaling using intracellular calcium source GO:0035584 IDA
Subcellular Localization
    dendrite GO:0030425 ISS
    neuron projection GO:0043005 ISS
    filopodium GO:0030175 ISS
    growth cone GO:0030426 ISS
    nucleus GO:0005634 ISS
    PML body GO:0016605 ISS
    postsynaptic membrane GO:0045211 ISS
    cell-cell junction GO:0005911 IDA
    cell junction GO:0030054 ISS
    integral component of plasma membrane GO:0005887 IEA
    plasma membrane GO:0005886 ISS
    intracellular GO:0005622 IDA
    endoplasmic reticulum GO:0005783 ISS
    synapse GO:0045202 ISS
    dendritic spine GO:0043197 ISS
    Golgi apparatus GO:0005794 ISS
 Experiment description of studies that identified TENM2 in exosomes
1
Experiment ID 363
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TENM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TENM2 is involved
No pathways found





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