Gene description for Slc30a1
Gene name solute carrier family 30 (zinc transporter), member 1
Gene symbol Slc30a1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Slc30a1
ExoCarta ExoCarta_58976
Entrez Gene 58976
UniProt Q62720  
 Slc30a1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Slc30a1
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IMP
    calcium channel inhibitor activity GO:0019855 ISO
Biological Process
    cellular calcium ion homeostasis GO:0006874 ISO
    detoxification of cadmium ion GO:0071585 IMP
    zinc II ion transport GO:0006829 ISO
    in utero embryonic development GO:0001701 ISO
    calcium ion import GO:0070509 IMP
    negative regulation of zinc ion transmembrane import GO:0071584 ISO
    negative regulation of neurotransmitter secretion GO:0046929 IMP
    negative regulation of calcium ion import GO:0090281 ISO
    cellular zinc ion homeostasis GO:0006882 ISO
    zinc II ion transmembrane transport GO:0071577 IDA
    cadmium ion transmembrane transport GO:0070574 IMP
Subcellular Localization
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 ISO
    nuclear membrane GO:0031965 ISO
    endoplasmic reticulum GO:0005783 ISO
    T-tubule GO:0030315 IDA
    integral component of membrane GO:0016021 IDA
    Golgi apparatus GO:0005794 ISO
    cell GO:0005623 ISO
 Experiment description of studies that identified Slc30a1 in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc30a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc30a1 is involved
PathwayEvidenceSource
Zinc efflux and compartmentalization by the SLC30 family IEA Reactome





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