Gene description for Slc30a1
Gene name solute carrier family 30 (zinc transporter), member 1
Gene symbol Slc30a1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Slc30a1
ExoCarta ExoCarta_58976
Vesiclepedia VP_58976
Entrez Gene 58976
UniProt Q62720  
 Slc30a1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Slc30a1
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 IDA
    zinc ion transmembrane transporter activity GO:0005385 IMP
    calcium channel inhibitor activity GO:0019855 IBA
    calcium channel inhibitor activity GO:0019855 IMP
    calcium channel inhibitor activity GO:0019855 ISO
    metal ion binding GO:0046872 IEA
    zinc:proton antiporter activity GO:0140826 IDA
Biological Process
    in utero embryonic development GO:0001701 ISO
    zinc ion transport GO:0006829 IDA
    zinc ion transport GO:0006829 IDA
    zinc ion transport GO:0006829 IMP
    zinc ion transport GO:0006829 ISO
    intracellular calcium ion homeostasis GO:0006874 ISO
    intracellular zinc ion homeostasis GO:0006882 IBA
    intracellular zinc ion homeostasis GO:0006882 ISO
    intracellular zinc ion homeostasis GO:0006882 ISO
    intracellular zinc ion homeostasis GO:0006882 ISS
    detoxification of zinc ion GO:0010312 IBA
    defense response to bacterium GO:0042742 ISO
    defense response to bacterium GO:0042742 ISS
    negative regulation of neurotransmitter secretion GO:0046929 IMP
    positive regulation of dendritic spine morphogenesis GO:0061003 IMP
    zinc ion import into organelle GO:0062111 ISO
    zinc ion import into organelle GO:0062111 ISS
    calcium ion import GO:0070509 IMP
    cadmium ion transmembrane transport GO:0070574 IMP
    zinc ion transmembrane transport GO:0071577 IBA
    negative regulation of zinc ion transmembrane import GO:0071584 ISO
    detoxification of cadmium ion GO:0071585 IMP
    negative regulation of calcium ion import GO:0090281 ISO
    zinc export across plasma membrane GO:0140882 IDA
    zinc export across plasma membrane GO:0140882 IMP
    regulation of postsynaptic density protein 95 clustering GO:1902897 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    cytoplasm GO:0005737 ISO
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 IBA
    basolateral plasma membrane GO:0016323 ISO
    basolateral plasma membrane GO:0016323 ISS
    T-tubule GO:0030315 IDA
    dendrite GO:0030425 IDA
    cytoplasmic vesicle membrane GO:0030659 ISO
    cytoplasmic vesicle membrane GO:0030659 ISS
    nuclear membrane GO:0031965 ISO
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    postsynaptic density membrane GO:0098839 IDA
    postsynaptic density, intracellular component GO:0099092 IDA
    glutamatergic postsynaptic density GO:0099573 IDA
 Experiment description of studies that identified Slc30a1 in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc30a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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