Gene description for Rrs1
Gene name RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
Gene symbol Rrs1
Other names/aliases 5730466A07Rik
AA415037
D1Ertd701e
Rrr
Species Mus musculus
 Database cross references - Rrs1
ExoCarta ExoCarta_59014
Vesiclepedia VP_59014
Entrez Gene 59014
UniProt Q9CYH6  
 Rrs1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rrs1
Molecular Function
    protein binding GO:0005515 IPI
    5S rRNA binding GO:0008097 ISO
    5S rRNA binding GO:0008097 ISS
Biological Process
    ribosomal large subunit assembly GO:0000027 ISO
    ribosomal large subunit assembly GO:0000027 ISS
    endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000447 IBA
    hematopoietic progenitor cell differentiation GO:0002244 IMP
    mitotic metaphase chromosome alignment GO:0007080 IEA
    mitotic metaphase chromosome alignment GO:0007080 ISO
    ribosomal large subunit biogenesis GO:0042273 IBA
    ribosomal large subunit biogenesis GO:0042273 ISO
    regulation of signal transduction by p53 class mediator GO:1901796 ISO
    regulation of signal transduction by p53 class mediator GO:1901796 ISS
    protein localization to nucleolus GO:1902570 ISO
    protein localization to nucleolus GO:1902570 ISS
Subcellular Localization
    condensed nuclear chromosome GO:0000794 IEA
    condensed nuclear chromosome GO:0000794 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    nucleolus GO:0005730 ISO
    endoplasmic reticulum GO:0005783 IDA
    preribosome, large subunit precursor GO:0030687 IBA
 Experiment description of studies that identified Rrs1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rrs1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Atxn1  
Affinity Capture-MS Mus musculus
3 Twist1  
Proximity Label-MS Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Cul7  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Rrs1 is involved
No pathways found





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