Gene description for Nup160
Gene name nucleoporin 160
Gene symbol Nup160
Other names/aliases 160kDa
2810011M03Rik
AA414952
AU020188
Gtl-13
Gtl1-13
Gtl13
mKIAA0197
Species Mus musculus
 Database cross references - Nup160
ExoCarta ExoCarta_59015
Vesiclepedia VP_59015
Entrez Gene 59015
UniProt Q9Z0W3  
 Nup160 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nup160
Molecular Function
    structural constituent of nuclear pore GO:0017056 IBA
    structural constituent of nuclear pore GO:0017056 IDA
    structural constituent of nuclear pore GO:0017056 ISO
Biological Process
    mRNA export from nucleus GO:0006406 IDA
    mRNA export from nucleus GO:0006406 ISO
    nucleocytoplasmic transport GO:0006913 NAS
    protein transport GO:0015031 IEA
    nephron development GO:0072006 ISO
Subcellular Localization
    kinetochore GO:0000776 ISO
    kinetochore GO:0000776 ISS
    nuclear envelope GO:0005635 ISO
    nuclear pore GO:0005643 IBA
    nuclear pore GO:0005643 IDA
    nuclear pore GO:0005643 ISO
    nuclear pore GO:0005643 NAS
    nuclear pore outer ring GO:0031080 ISO
    nuclear pore outer ring GO:0031080 ISS
 Experiment description of studies that identified Nup160 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nup160
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Cebpa  
Affinity Capture-MS Mus musculus
3 Eed  
Affinity Capture-MS Mus musculus
4 Fitm2  
Negative Genetic Mus musculus
View the network image/svg+xml
 Pathways in which Nup160 is involved
PathwayEvidenceSource
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal IEA Reactome
Amplification of signal from the kinetochores IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular response to heat stress IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
EML4 and NUDC in mitotic spindle formation IEA Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA IEA Reactome
Glucose metabolism IEA Reactome
Glycolysis IEA Reactome
M Phase IEA Reactome
Metabolism IEA Reactome
Metabolism of carbohydrates IEA Reactome
Metabolism of non-coding RNA IEA Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA IEA Reactome
Mitotic Anaphase IEA Reactome
Mitotic Metaphase and Anaphase IEA Reactome
Mitotic Prometaphase IEA Reactome
Mitotic Prophase IEA Reactome
Mitotic Spindle Checkpoint IEA Reactome
Nuclear Envelope (NE) Reassembly IEA Reactome
Nuclear Envelope Breakdown IEA Reactome
Nuclear Pore Complex (NPC) Disassembly IEA Reactome
Post-translational protein modification IEA Reactome
Postmitotic nuclear pore complex (NPC) reformation IEA Reactome
Processing of Capped Intron-Containing Pre-mRNA IEA Reactome
Regulation of Glucokinase by Glucokinase Regulatory Protein IEA Reactome
Regulation of HSF1-mediated heat shock response IEA Reactome
Resolution of Sister Chromatid Cohesion IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases Activate Formins IEA Reactome
Separation of Sister Chromatids IEA Reactome
Signal Transduction IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
snRNP Assembly IEA Reactome
SUMO E3 ligases SUMOylate target proteins IEA Reactome
SUMOylation IEA Reactome
SUMOylation of chromatin organization proteins IEA Reactome
SUMOylation of DNA damage response and repair proteins IEA Reactome
SUMOylation of DNA replication proteins IEA Reactome
SUMOylation of RNA binding proteins IEA Reactome
SUMOylation of SUMOylation proteins IEA Reactome
SUMOylation of ubiquitinylation proteins IEA Reactome
Transcriptional regulation by small RNAs IEA Reactome
Transport of Mature mRNA derived from an Intron-Containing Transcript IEA Reactome
Transport of Mature mRNA Derived from an Intronless Transcript IEA Reactome
Transport of Mature mRNAs Derived from Intronless Transcripts IEA Reactome
Transport of Mature Transcript to Cytoplasm IEA Reactome
Transport of the SLBP Dependant Mature mRNA IEA Reactome
Transport of the SLBP independent Mature mRNA IEA Reactome





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