Gene description for Bhlhe22
Gene name basic helix-loop-helix family, member e22
Gene symbol Bhlhe22
Other names/aliases Beta3
Bhlhb5
Species Mus musculus
 Database cross references - Bhlhe22
ExoCarta ExoCarta_59058
Vesiclepedia VP_59058
Entrez Gene 59058
UniProt Q8C6A8  
 Bhlhe22 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Bhlhe22
Molecular Function
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IMP
    chromatin binding GO:0003682 IDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    protein dimerization activity GO:0046983 IEA
    E-box binding GO:0070888 IBA
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    sensory organ development GO:0007423 IBA
    corpus callosum morphogenesis GO:0021540 IMP
    cerebral cortex regionalization GO:0021796 IMP
    central nervous system projection neuron axonogenesis GO:0021952 IMP
    corticospinal tract morphogenesis GO:0021957 IGI
    corticospinal tract morphogenesis GO:0021957 IMP
    anterior commissure morphogenesis GO:0021960 IMP
    amacrine cell differentiation GO:0035881 IMP
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    retinal bipolar neuron differentiation GO:0060040 IMP
    retina morphogenesis in camera-type eye GO:0060042 IMP
    axon development GO:0061564 IBA
    GABAergic neuron differentiation GO:0097154 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified Bhlhe22 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Bhlhe22
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Bhlhe22 is involved
No pathways found





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