Gene description for Slc9a3r1
Gene name solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Gene symbol Slc9a3r1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Slc9a3r1
ExoCarta ExoCarta_59114
Vesiclepedia VP_59114
Entrez Gene 59114
UniProt Q9JJ19  
 Slc9a3r1 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Slc9a3r1
Molecular Function
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 ISO
    gamma-aminobutyric acid transmembrane transporter activity GO:0015185 IGI
    chloride channel regulator activity GO:0017081 ISO
    chloride channel regulator activity GO:0017081 ISS
    phosphatase binding GO:0019902 ISO
    protein domain specific binding GO:0019904 IPI
    PDZ domain binding GO:0030165 IPI
    PDZ domain binding GO:0030165 ISO
    beta-2 adrenergic receptor binding GO:0031698 ISO
    type 2 metabotropic glutamate receptor binding GO:0031799 ISO
    type 3 metabotropic glutamate receptor binding GO:0031800 ISO
    identical protein binding GO:0042802 ISO
    protein-membrane adaptor activity GO:0043495 IBA
    transmembrane transporter binding GO:0044325 IPI
    protein-containing complex binding GO:0044877 IPI
    myosin II binding GO:0045159 IDA
    dopamine receptor binding GO:0050780 ISO
    molecular adaptor activity GO:0060090 IMP
    growth factor receptor binding GO:0070851 ISO
    channel activator activity GO:0099103 ISO
Biological Process
    renal sodium ion transport GO:0003096 ISO
    sodium ion transport GO:0006814 ISO
    plasma membrane organization GO:0007009 ISO
    nuclear migration GO:0007097 ISO
    adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 ISO
    sensory perception of sound GO:0007605 ISO
    protein localization GO:0008104 ISO
    negative regulation of cell population proliferation GO:0008285 ISO
    regulation of cell shape GO:0008360 ISO
    regulation of cell size GO:0008361 ISO
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 ISO
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 ISS
    fibroblast migration GO:0010761 ISO
    negative regulation of fibroblast migration GO:0010764 ISO
    negative regulation of sodium ion transport GO:0010766 ISO
    Wnt signaling pathway GO:0016055 IEA
    gland morphogenesis GO:0022612 ISO
    microvillus assembly GO:0030033 ISO
    actin cytoskeleton organization GO:0030036 ISO
    intracellular phosphate ion homeostasis GO:0030643 ISO
    negative regulation of sodium:proton antiporter activity GO:0032416 ISO
    bile acid secretion GO:0032782 ISO
    bile acid secretion GO:0032782 ISS
    glutathione transport GO:0034635 ISO
    glutathione transport GO:0034635 ISS
    positive regulation of monoatomic ion transmembrane transport GO:0034767 IDA
    cilium organization GO:0044782 ISO
    establishment of epithelial cell apical/basal polarity GO:0045198 ISO
    maintenance of epithelial cell apical/basal polarity GO:0045199 ISO
    regulation of protein kinase activity GO:0045859 ISO
    regulation of protein kinase activity GO:0045859 ISS
    negative regulation of mitotic cell cycle GO:0045930 ISO
    establishment of localization in cell GO:0051649 ISO
    establishment of localization in cell GO:0051649 ISO
    establishment of Golgi localization GO:0051683 ISO
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 ISO
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 ISO
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 ISS
    gamma-aminobutyric acid import GO:0051939 IGI
    auditory receptor cell stereocilium organization GO:0060088 ISO
    phospholipase C-activating dopamine receptor signaling pathway GO:0060158 ISO
    renal absorption GO:0070293 ISO
    renal absorption GO:0070293 ISS
    negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO
    protein localization to plasma membrane GO:0072659 IBA
    protein localization to plasma membrane GO:0072659 ISO
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISO
    cerebrospinal fluid circulation GO:0090660 ISO
    renal phosphate ion absorption GO:0097291 ISO
    renal phosphate ion absorption GO:0097291 ISS
    import across plasma membrane GO:0098739 IGI
    regulation of renal phosphate excretion GO:1903402 ISO
    negative regulation of cell motility GO:2000146 ISO
    negative regulation of cell motility GO:2000146 ISS
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO
Subcellular Localization
    ruffle GO:0001726 IEA
    extracellular region GO:0005576 IEA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    microvillus GO:0005902 ISO
    endomembrane system GO:0012505 IEA
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
    apical plasma membrane GO:0016324 IBA
    apical plasma membrane GO:0016324 IDA
    apical plasma membrane GO:0016324 ISO
    filopodium GO:0030175 IEA
    brush border membrane GO:0031526 ISO
    microvillus membrane GO:0031528 IDA
    stereocilium GO:0032420 ISO
    stereocilium tip GO:0032426 ISO
    apical part of cell GO:0045177 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    cell periphery GO:0071944 ISO
    sperm midpiece GO:0097225 ISO
    sperm midpiece GO:0097225 ISS
    plasma membrane protein complex GO:0098797 IPI
 Experiment description of studies that identified Slc9a3r1 in exosomes
1
Experiment ID 192
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc9a3r1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Abcc2  
Reconstituted Complex Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Slc9a3r1 is involved
No pathways found





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