Gene description for Slc9a3r1
Gene name solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Gene symbol Slc9a3r1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Slc9a3r1
ExoCarta ExoCarta_59114
Entrez Gene 59114
UniProt Q9JJ19  
 Slc9a3r1 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Slc9a3r1
Molecular Function
    dopamine receptor binding GO:0050780 ISO
    growth factor receptor binding GO:0070851 ISO
    chloride channel regulator activity GO:0017081 ISS
    PDZ domain binding GO:0030165 ISO
    beta-2 adrenergic receptor binding GO:0031698 ISO
    receptor binding GO:0005102 ISO
    protein complex binding GO:0032403 IPI
    phosphatase binding GO:0019902 ISO
    protein domain specific binding GO:0019904 IPI
    protein complex scaffold GO:0032947 IMP
    protein self-association GO:0043621 ISO
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 ISO
Biological Process
    cAMP-mediated signaling GO:0019933 ISO
    phospholipase C-activating dopamine receptor signaling pathway GO:0060158 ISO
    negative regulation of sodium ion transport GO:0010766 ISO
    renal absorption GO:0070293 ISS
    microvillus assembly GO:0030033 ISO
    bile acid secretion GO:0032782 ISS
    negative regulation of sodium:proton antiporter activity GO:0032416 ISO
    negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO
    Wnt signaling pathway GO:0016055 IEA
    adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 ISO
    negative regulation of protein kinase B signaling GO:0051898 ISS
    auditory receptor cell stereocilium organization GO:0060088 ISO
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO
    cellular phosphate ion homeostasis GO:0030643 ISO
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 ISS
    actin cytoskeleton organization GO:0030036 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    cellular protein localization GO:0034613 ISO
    negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067 ISS
    regulation of excretion GO:0044062 ISO
    regulation of protein kinase activity GO:0045859 ISS
    sensory perception of sound GO:0007605 ISO
    glutathione transport GO:0034635 ISS
    renal phosphate ion absorption GO:0097291 ISS
    negative regulation of cell motility GO:2000146 ISS
    renal sodium ion transport GO:0003096 ISO
    negative regulation of cell migration GO:0030336 ISO
Subcellular Localization
    filopodium GO:0030175 IEA
    cell periphery GO:0071944 ISO
    vesicle GO:0031982 ISO
    extracellular exosome GO:0070062 ISO
    sperm midpiece GO:0097225 ISS
    cytoplasm GO:0005737 ISO
    brush border membrane GO:0031526 ISO
    membrane raft GO:0045121 IDA
    intracellular GO:0005622 ISO
    stereocilium bundle tip GO:0032426 ISO
    centrosome GO:0005813 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    plasma membrane GO:0005886 ISO
    stereocilium GO:0032420 ISO
    nucleus GO:0005634 ISO
    apical plasma membrane GO:0016324 ISO
    microvillus GO:0005902 ISO
    apical part of cell GO:0045177 ISO
    cell GO:0005623 ISO
    microvillus membrane GO:0031528 IDA
    membrane GO:0016020 ISS
    ruffle GO:0001726 IEA
    endomembrane system GO:0012505 IEA
 Experiment description of studies that identified Slc9a3r1 in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc9a3r1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc9a3r1 is involved
No pathways found





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