Gene description for Cd14
Gene name CD14 molecule
Gene symbol Cd14
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Cd14
ExoCarta ExoCarta_60350
Vesiclepedia VP_60350
Entrez Gene 60350
UniProt Q63691  
 Cd14 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Cd14
Molecular Function
    lipopolysaccharide binding GO:0001530 IBA
    lipopolysaccharide binding GO:0001530 ISO
    lipopolysaccharide immune receptor activity GO:0001875 ISO
    protein binding GO:0005515 IPI
    lipoteichoic acid binding GO:0070891 ISO
Biological Process
    positive regulation of cytokine production GO:0001819 IBA
    positive regulation of cytokine production GO:0001819 IMP
    response to molecule of bacterial origin GO:0002237 ISO
    cell surface pattern recognition receptor signaling pathway GO:0002752 ISO
    receptor-mediated endocytosis GO:0006898 ISO
    inflammatory response GO:0006954 IEA
    response to bacterium GO:0009617 ISO
    response to bacterium GO:0009617 ISO
    response to bacterium GO:0009617 ISS
    lipopolysaccharide-mediated signaling pathway GO:0031663 IEA
    positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 ISO
    positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 ISS
    response to magnesium ion GO:0032026 IEP
    positive regulation of type I interferon production GO:0032481 ISO
    response to lipopolysaccharide GO:0032496 IEP
    positive regulation of type II interferon production GO:0032729 ISO
    positive regulation of type II interferon production GO:0032729 ISS
    positive regulation of interleukin-8 production GO:0032757 ISO
    positive regulation of tumor necrosis factor production GO:0032760 ISO
    positive regulation of tumor necrosis factor production GO:0032760 ISO
    positive regulation of tumor necrosis factor production GO:0032760 ISS
    toll-like receptor 4 signaling pathway GO:0034142 IBA
    toll-like receptor 4 signaling pathway GO:0034142 ISO
    positive regulation of toll-like receptor 4 signaling pathway GO:0034145 ISO
    positive regulation of toll-like receptor 4 signaling pathway GO:0034145 ISS
    response to tumor necrosis factor GO:0034612 IMP
    innate immune response GO:0045087 IEA
    response to ethanol GO:0045471 IEP
    positive regulation of endocytosis GO:0045807 ISO
    response to electrical stimulus GO:0051602 IEP
    cellular response to lipopolysaccharide GO:0071222 IBA
    cellular response to lipopolysaccharide GO:0071222 IEP
    cellular response to lipopolysaccharide GO:0071222 ISO
    cellular response to lipopolysaccharide GO:0071222 ISO
    cellular response to lipopolysaccharide GO:0071222 ISS
    cellular response to lipoteichoic acid GO:0071223 ISO
    cellular response to diacyl bacterial lipopeptide GO:0071726 ISO
    cellular response to diacyl bacterial lipopeptide GO:0071726 ISS
    cellular response to triacyl bacterial lipopeptide GO:0071727 ISO
    cellular response to triacyl bacterial lipopeptide GO:0071727 ISS
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    Golgi apparatus GO:0005794 ISO
    Golgi apparatus GO:0005794 ISS
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 ISO
    external side of plasma membrane GO:0009897 ISS
    cell surface GO:0009986 IDA
    membrane raft GO:0045121 IBA
    membrane raft GO:0045121 ISO
    membrane raft GO:0045121 ISS
    lipopolysaccharide receptor complex GO:0046696 IBA
    lipopolysaccharide receptor complex GO:0046696 ISO
    lipopolysaccharide receptor complex GO:0046696 ISS
    lipopolysaccharide receptor complex GO:0046696 TAS
 Experiment description of studies that identified Cd14 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Cd14
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here