Gene description for Wtap
Gene name Wilms tumour 1-associating protein
Gene symbol Wtap
Other names/aliases 2810408K05Rik
9430038B09Rik
Species Mus musculus
 Database cross references - Wtap
ExoCarta ExoCarta_60532
Entrez Gene 60532
UniProt Q9ER69  
 Wtap identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Wtap
Biological Process
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 ISO
    regulation of mRNA splicing, via spliceosome GO:0048024 IEA
    mRNA methylation GO:0080009 ISO
    cell cycle GO:0007049 IEA
    multicellular organismal development GO:0007275 IEA
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 IEA
Subcellular Localization
    MIS complex GO:0036396 ISO
    nucleus GO:0005634 ISO
    nuclear membrane GO:0031965 ISO
    nucleoplasm GO:0005654 ISO
    nuclear speck GO:0016607 ISO
 Experiment description of studies that identified Wtap in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Wtap
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Wtap is involved
No pathways found





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