Gene description for Acaca
Gene name acetyl-CoA carboxylase alpha
Gene symbol Acaca
Other names/aliases ACC1
Acac
Species Rattus norvegicus
 Database cross references - Acaca
ExoCarta ExoCarta_60581
Entrez Gene 60581
UniProt P11497  
 Acaca identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Acaca
Molecular Function
    acetyl-CoA carboxylase activity GO:0003989 ISO
    kinase binding GO:0019900 IPI
    metal ion binding GO:0046872 IEA
    ATP binding GO:0005524 IEA
    biotin binding GO:0009374 IMP
    biotin carboxylase activity GO:0004075 IEA
Biological Process
    protein homotetramerization GO:0051289 ISS
    response to drug GO:0042493 IEP
    acetyl-CoA metabolic process GO:0006084 ISO
    fatty acid biosynthetic process GO:0006633 ISO
    multicellular organismal protein metabolic process GO:0044268 ISO
    lipid metabolic process GO:0006629 ISO
    response to organic cyclic compound GO:0014070 IMP
    malonyl-CoA biosynthetic process GO:2001295 IEA
    cellular response to prostaglandin E stimulus GO:0071380 ISO
    tissue homeostasis GO:0001894 ISO
    lipid homeostasis GO:0055088 ISO
Subcellular Localization
    actin cytoskeleton GO:0015629 ISO
    extracellular exosome GO:0070062 ISO
    mitochondrion GO:0005739 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISS
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Acaca in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Acaca
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Acaca is involved
No pathways found





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