Gene description for Acaca
Gene name acetyl-CoA carboxylase alpha
Gene symbol Acaca
Other names/aliases ACC1
Acac
Species Rattus norvegicus
 Database cross references - Acaca
ExoCarta ExoCarta_60581
Vesiclepedia VP_60581
Entrez Gene 60581
UniProt P11497  
 Acaca identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Acaca
Molecular Function
    acetyl-CoA carboxylase activity GO:0003989 IBA
    acetyl-CoA carboxylase activity GO:0003989 IDA
    acetyl-CoA carboxylase activity GO:0003989 IEA
    acetyl-CoA carboxylase activity GO:0003989 ISO
    ATP binding GO:0005524 IEA
    biotin binding GO:0009374 IDA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    tissue homeostasis GO:0001894 IEA
    tissue homeostasis GO:0001894 ISO
    acetyl-CoA metabolic process GO:0006084 IEA
    acetyl-CoA metabolic process GO:0006084 ISO
    lipid metabolic process GO:0006629 ISO
    fatty acid biosynthetic process GO:0006633 IBA
    fatty acid biosynthetic process GO:0006633 IDA
    fatty acid biosynthetic process GO:0006633 IEA
    fatty acid biosynthetic process GO:0006633 ISO
    response to nutrient GO:0007584 IEP
    lipid biosynthetic process GO:0008610 ISO
    response to xenobiotic stimulus GO:0009410 IEP
    response to organic cyclic compound GO:0014070 IMP
    response to nutrient levels GO:0031667 IEP
    protein homotetramerization GO:0051289 IEA
    protein homotetramerization GO:0051289 ISO
    protein homotetramerization GO:0051289 ISS
    lipid homeostasis GO:0055088 IEA
    lipid homeostasis GO:0055088 ISO
    cellular response to prostaglandin E stimulus GO:0071380 IEA
    cellular response to prostaglandin E stimulus GO:0071380 ISO
    malonyl-CoA biosynthetic process GO:2001295 IEA
Subcellular Localization
    fibrillar center GO:0001650 IEA
    fibrillar center GO:0001650 ISO
    cytoplasm GO:0005737 IEA
    mitochondrion GO:0005739 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    actin cytoskeleton GO:0015629 IEA
    actin cytoskeleton GO:0015629 ISO
 Experiment description of studies that identified Acaca in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Acaca
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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