Gene description for Trp53inp1
Gene name transformation related protein 53 inducible nuclear protein 1
Gene symbol Trp53inp1
Other names/aliases 2700057G22Rik
SIP
SIP18
SIP27
Stinp
Teap
Species Mus musculus
 Database cross references - Trp53inp1
ExoCarta ExoCarta_60599
Entrez Gene 60599
UniProt Q9QXE4  
 Trp53inp1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Trp53inp1
Molecular Function
    antioxidant activity GO:0016209 IMP
Biological Process
    negative regulation of cell proliferation GO:0008285 IMP
    positive regulation of apoptotic signaling pathway GO:2001235 IGI
    negative regulation of cell migration GO:0030336 IMP
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    positive regulation of apoptotic process GO:0043065 IDA
    transcription, DNA-templated GO:0006351 IEA
    cellular response to UV GO:0034644 IDA
    autophagic cell death GO:0048102 ISO
    positive regulation of autophagy GO:0010508 ISO
    response to heat GO:0009408 IDA
    cellular response to hydroperoxide GO:0071447 IDA
    autophagosome assembly GO:0000045 IBA
    cellular response to ethanol GO:0071361 IDA
    apoptotic process GO:0006915 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    regulation of autophagy GO:0010506 IEA
    cell cycle arrest GO:0007050 IDA
    cellular response to methyl methanesulfonate GO:0072703 IDA
    autophagy GO:0006914 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IEA
    nucleolus GO:0005730 IDA
    autophagosome GO:0005776 ISO
    cytosol GO:0005829 ISO
    cytoplasmic vesicle GO:0031410 IEA
 Experiment description of studies that identified Trp53inp1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Trp53inp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Trp53inp1 is involved
No pathways found





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