Gene description for UBE2M
Gene name ubiquitin-conjugating enzyme E2M
Gene symbol UBE2M
Other names/aliases -
Species Bos taurus
 Database cross references - UBE2M
ExoCarta ExoCarta_613343
Entrez Gene 613343
UniProt A3KN22  
 UBE2M identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for UBE2M
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 ISS
    ubiquitin protein ligase activity GO:0061630 IBA
    ribosomal S6-glutamic acid ligase activity GO:0018169 ISS
    ubiquitin protein ligase binding GO:0031625 IBA
    NEDD8 transferase activity GO:0019788 ISS
    ATP binding GO:0005524 IEA
Biological Process
    protein ubiquitination GO:0016567 IBA
    cellular protein modification process GO:0006464 ISS
    protein neddylation GO:0045116 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified UBE2M in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBE2M
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which UBE2M is involved
PathwayEvidenceSource
TGF-beta receptor signaling activates SMADs IEA Reactome





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