Gene description for UBE2M
Gene name ubiquitin-conjugating enzyme E2M
Gene symbol UBE2M
Other names/aliases -
Species Bos taurus
 Database cross references - UBE2M
ExoCarta ExoCarta_613343
Entrez Gene 613343
UniProt A3KN22  
 UBE2M identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for UBE2M
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 ISS
    ubiquitin protein ligase activity GO:0061630 IBA
    ribosomal S6-glutamic acid ligase activity GO:0018169 ISS
    ubiquitin protein ligase binding GO:0031625 IBA
    NEDD8 transferase activity GO:0019788 ISS
    ATP binding GO:0005524 IEA
Biological Process
    protein ubiquitination GO:0016567 IBA
    cellular protein modification process GO:0006464 ISS
    protein neddylation GO:0045116 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified UBE2M in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBE2M
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which UBE2M is involved
TGF-beta receptor signaling activates SMADs IEA Reactome

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