Gene description for CHMP4A
Gene name charged multivesicular body protein 4A
Gene symbol CHMP4A
Other names/aliases -
Species Bos taurus
 Database cross references - CHMP4A
ExoCarta ExoCarta_613647
Entrez Gene 613647
UniProt A2VDY3  
 CHMP4A identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for CHMP4A
Molecular Function
    protein homodimerization activity GO:0042803 IEA
    lipid binding GO:0008289 IEA
    ATPase binding GO:0051117 IEA
Biological Process
    negative regulation of autophagosome assembly GO:1902902 IEA
    cell separation after cytokinesis GO:0000920 IEA
    vacuolar transport GO:0007034 IEA
    viral budding via host ESCRT complex GO:0039702 IEA
    membrane tubulation GO:0097320 IEA
    nucleus organization GO:0006997 IEA
    posttranslational protein targeting to membrane GO:0006620 IEA
    mitotic metaphase plate congression GO:0007080 IEA
    negative regulation of neuron death GO:1901215 IEA
    protein homooligomerization GO:0051260 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    midbody GO:0030496 IEA
    cytoplasmic vesicle membrane GO:0030659 IEA
    ESCRT III complex GO:0000815 IEA
    extracellular exosome GO:0070062 IEA
    cytoplasmic side of plasma membrane GO:0009898 IEA
    late endosome membrane GO:0031902 IEA
 Experiment description of studies that identified CHMP4A in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CHMP4A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CHMP4A is involved
PathwayEvidenceSource
Endosomal Sorting Complex Required For Transport (ESCRT) IEA Reactome





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