Gene description for MAPKAPK3
Gene name mitogen-activated protein kinase-activated protein kinase 3
Gene symbol MAPKAPK3
Other names/aliases MAPKAP-K3
MK-3
Species Bos taurus
 Database cross references - MAPKAPK3
ExoCarta ExoCarta_615215
Vesiclepedia VP_615215
Entrez Gene 615215
UniProt Q3SYZ2  
 MAPKAPK3 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for MAPKAPK3
Molecular Function
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IEA
    calmodulin binding GO:0005516 IEA
    ATP binding GO:0005524 IEA
    calcium-dependent protein serine/threonine kinase activity GO:0009931 IEA
    mitogen-activated protein kinase binding GO:0051019 IEA
Biological Process
    toll-like receptor signaling pathway GO:0002224 IEA
    peptidyl-serine phosphorylation GO:0018105 IEA
    response to cytokine GO:0034097 IEA
    intracellular signal transduction GO:0035556 IEA
    protein autophosphorylation GO:0046777 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified MAPKAPK3 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MAPKAPK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MAPKAPK3 is involved
PathwayEvidenceSource
activated TAK1 mediates p38 MAPK activation IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence IEA Reactome
Cytokine Signaling in Immune system IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Interleukin-17 signaling IEA Reactome
MAP kinase activation IEA Reactome
MyD88 cascade initiated on plasma membrane IEA Reactome
MyD88 dependent cascade initiated on endosome IEA Reactome
MyD88-independent TLR4 cascade IEA Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane IEA Reactome
Oxidative Stress Induced Senescence IEA Reactome
p38MAPK events IEA Reactome
Signal Transduction IEA Reactome
Signaling by Interleukins IEA Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by VEGF IEA Reactome
Signalling to ERKs IEA Reactome
Signalling to RAS IEA Reactome
Toll Like Receptor 10 (TLR10) Cascade IEA Reactome
Toll Like Receptor 2 (TLR2) Cascade IEA Reactome
Toll Like Receptor 3 (TLR3) Cascade IEA Reactome
Toll Like Receptor 4 (TLR4) Cascade IEA Reactome
Toll Like Receptor 5 (TLR5) Cascade IEA Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade IEA Reactome
Toll Like Receptor 9 (TLR9) Cascade IEA Reactome
Toll Like Receptor TLR1:TLR2 Cascade IEA Reactome
Toll Like Receptor TLR6:TLR2 Cascade IEA Reactome
Toll-like Receptor Cascades IEA Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IEA Reactome
TRIF (TICAM1)-mediated TLR4 signaling IEA Reactome
VEGFA-VEGFR2 Pathway IEA Reactome





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