Gene description for NME2
Gene name non-metastatic cells 2, protein (NM23B) expressed in
Gene symbol NME2
Other names/aliases -
Species Bos taurus
 Database cross references - NME2
ExoCarta ExoCarta_615447
Entrez Gene 615447
UniProt Q3T0Q4  
 NME2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for NME2
Molecular Function
    protein histidine kinase activity GO:0004673 IEA
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    nucleoside diphosphate kinase activity GO:0004550 IEA
Biological Process
    CTP biosynthetic process GO:0006241 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    nucleoside diphosphate phosphorylation GO:0006165 IEA
    peptidyl-histidine phosphorylation GO:0018106 IEA
    UTP biosynthetic process GO:0006228 IEA
    GTP biosynthetic process GO:0006183 IEA
    integrin-mediated signaling pathway GO:0007229 ISS
Subcellular Localization
    lamellipodium GO:0030027 ISS
    cytoplasm GO:0005737 ISS
    ruffle GO:0001726 ISS
    cell periphery GO:0071944 ISS
    plasma membrane GO:0005886 IEA
    focal adhesion GO:0005925 ISS
 Experiment description of studies that identified NME2 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NME2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NME2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here