Gene description for FIS1
Gene name fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Gene symbol FIS1
Other names/aliases -
Species Bos taurus
 Database cross references - FIS1
ExoCarta ExoCarta_615565
Entrez Gene 615565
UniProt Q3T0I5  
 FIS1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for FIS1
Molecular Function
    receptor binding GO:0005102 IEA
Biological Process
    mitochondrion morphogenesis GO:0070584 IEA
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IEA
    positive regulation of protein targeting to membrane GO:0090314 ISS
    protein targeting to mitochondrion GO:0006626 IEA
    protein homooligomerization GO:0051260 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IEA
    positive regulation of mitochondrial calcium ion concentration GO:0051561 IEA
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 IEA
    positive regulation of mitochondrial fission GO:0090141 ISS
    peroxisome fission GO:0016559 IEA
    negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 IEA
    release of cytochrome c from mitochondria GO:0001836 IEA
    calcium-mediated signaling using intracellular calcium source GO:0035584 IEA
    mitochondrial fragmentation involved in apoptotic process GO:0043653 IEA
    mitochondrial fusion GO:0008053 ISS
    mitochondrion degradation GO:0000422 IEA
    mitochondrial fission GO:0000266 ISS
Subcellular Localization
    protein complex GO:0043234 IEA
    peroxisome GO:0005777 ISS
    integral component of mitochondrial outer membrane GO:0031307 IEA
    cytosol GO:0005829 IEA
    integral component of peroxisomal membrane GO:0005779 IEA
    endoplasmic reticulum GO:0005783 IEA
 Experiment description of studies that identified FIS1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FIS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FIS1 is involved
No pathways found





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