Gene description for S100A8
Gene name S100 calcium binding protein A8
Gene symbol S100A8
Other names/aliases -
Species Bos taurus
 Database cross references - S100A8
ExoCarta ExoCarta_616818
Entrez Gene 616818
UniProt P28782  
 S100A8 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for S100A8
Molecular Function
    calcium ion binding GO:0005509 IEA
    Toll-like receptor 4 binding GO:0035662 IEA
    microtubule binding GO:0008017 IEA
    arachidonic acid binding GO:0050544 IEA
    RAGE receptor binding GO:0050786 IEA
    antioxidant activity GO:0016209 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    innate immune response GO:0045087 IEA
    leukocyte migration involved in inflammatory response GO:0002523 ISS
    positive regulation of peptide secretion GO:0002793 IEA
    neutrophil aggregation GO:0070488 ISS
    autophagy GO:0006914 ISS
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 ISS
    neutrophil chemotaxis GO:0030593 ISS
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISS
    positive regulation of inflammatory response GO:0050729 ISS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoskeleton GO:0005856 IEA
    extracellular space GO:0005615 IEA
    extracellular exosome GO:0070062 IEA
    plasma membrane GO:0005886 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified S100A8 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for S100A8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which S100A8 is involved
No pathways found

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