Gene description for COTL1
Gene name coactosin-like F-actin binding protein 1
Gene symbol COTL1
Other names/aliases -
Species Bos taurus
 Database cross references - COTL1
ExoCarta ExoCarta_617165
Vesiclepedia VP_617165
Entrez Gene 617165
UniProt Q2HJ57  
 COTL1 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for COTL1
Molecular Function
    actin filament binding GO:0051015 IEA
Biological Process
    regulation of actin filament polymerization GO:0030833 IEA
Subcellular Localization
    actin filament GO:0005884 IEA
    plasma membrane GO:0005886 IEA
    site of polarized growth GO:0030427 IEA
    cortical actin cytoskeleton GO:0030864 IEA
 Experiment description of studies that identified COTL1 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COTL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which COTL1 is involved
PathwayEvidenceSource
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here