Gene description for GCHFR
Gene name GTP cyclohydrolase I feedback regulator
Gene symbol GCHFR
Other names/aliases -
Species Bos taurus
 Database cross references - GCHFR
ExoCarta ExoCarta_617650
Entrez Gene 617650
UniProt Q32L41  
 GCHFR identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for GCHFR
Biological Process
    negative regulation of biosynthetic process GO:0009890 IEA
Subcellular Localization
    dendrite GO:0030425 IEA
    melanosome GO:0042470 IEA
    cytosol GO:0005829 IEA
    nuclear membrane GO:0031965 IEA
 Experiment description of studies that identified GCHFR in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GCHFR
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GCHFR is involved
PathwayEvidenceSource
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation IEA Reactome





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