Gene description for PHPT1
Gene name phosphohistidine phosphatase 1
Gene symbol PHPT1
Other names/aliases PHP14
Species Bos taurus
 Database cross references - PHPT1
ExoCarta ExoCarta_618691
Entrez Gene 618691
UniProt Q32PA4  
 PHPT1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PHPT1
Molecular Function
    calcium channel inhibitor activity GO:0019855 IEA
    phosphoprotein phosphatase activity GO:0004721 IEA
    ion channel binding GO:0044325 IEA
    phosphohistidine phosphatase activity GO:0008969 IBA
Biological Process
    peptidyl-histidine dephosphorylation GO:0035971 IBA
    negative regulation of ATP citrate synthase activity GO:2000984 IEA
    positive regulation of cell motility GO:2000147 IEA
    negative regulation of T cell receptor signaling pathway GO:0050860 IEA
    regulation of actin cytoskeleton reorganization GO:2000249 IEA
    negative regulation of lyase activity GO:0051350 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    cytosol GO:0005829 IBA
 Experiment description of studies that identified PHPT1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PHPT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PHPT1 is involved
No pathways found





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