Gene description for ERVK-6
Gene name endogenous retrovirus group K, member 6
Gene symbol ERVK-6
Other names/aliases ERVK6
HERV-K(C7)
HERV-K108
K-Rev
c-orf
cORF
Species Homo sapiens
 Database cross references - ERVK-6
ExoCarta ExoCarta_64006
Entrez Gene 64006
HGNC 13915
MIM 605626
 ERVK-6 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ERVK-6
Molecular Function
    zinc ion binding GO:0008270 IEA
    aspartic-type endopeptidase activity GO:0004190 IEA
    DNA binding GO:0003677 IEA
    RNA-DNA hybrid ribonuclease activity GO:0004523 IEA
    structural molecule activity GO:0005198 IEA
    RNA-directed DNA polymerase activity GO:0003964 IEA
    DNA-directed DNA polymerase activity GO:0003887 IEA
    nucleic acid binding GO:0003676 IEA
    RNA binding GO:0003723 IEA
Biological Process
    mRNA transport GO:0051028 IEA
    dUTP metabolic process GO:0046080 IEA
    RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 IEA
    DNA recombination GO:0006310 IEA
    DNA biosynthetic process GO:0071897 IEA
    RNA-dependent DNA replication GO:0006278 IEA
    DNA integration GO:0015074 IEA
    proteolysis GO:0006508 IEA
    viral process GO:0016032 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IEA
    viral envelope GO:0019031 IEA
    cytoplasm GO:0005737 IEA
    viral capsid GO:0019028 IEA
    nucleolus GO:0005730 IEA
 Experiment description of studies that identified ERVK-6 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ERVK-6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ERVK-6 is involved
No pathways found





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