Gene description for ERVK-6
Gene name endogenous retrovirus group K, member 6
Gene symbol ERVK-6
Other names/aliases ERVK6
HERV-K(C7)
HERV-K108
K-Rev
c-orf
cORF
Species Homo sapiens
 Database cross references - ERVK-6
ExoCarta ExoCarta_64006
Vesiclepedia VP_64006
Entrez Gene 64006
HGNC 13915
MIM 605626
 ERVK-6 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ERVK-6
Molecular Function
    nucleic acid binding GO:0003676 IEA
    DNA binding GO:0003677 IEA
    telomerase activity GO:0003720 IEA
    RNA binding GO:0003723 IDA
    RNA binding GO:0003723 IMP
    aspartic-type endopeptidase activity GO:0004190 IEA
    RNA-DNA hybrid ribonuclease activity GO:0004523 IEA
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    RNA stem-loop binding GO:0035613 IBA
    RNA stem-loop binding GO:0035613 IDA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    DNA synthesis involved in DNA repair GO:0000731 IEA
    syncytium formation by plasma membrane fusion GO:0000768 IDA
    DNA-templated DNA replication GO:0006261 IEA
    RNA-templated DNA biosynthetic process GO:0006278 IEA
    DNA recombination GO:0006310 IEA
    mRNA export from nucleus GO:0006406 IDA
    mRNA export from nucleus GO:0006406 IMP
    proteolysis GO:0006508 IEA
    positive regulation of gene expression GO:0010628 IDA
    positive regulation of gene expression GO:0010628 IMP
    DNA integration GO:0015074 IEA
    protein homooligomerization GO:0051260 IMP
    viral translational frameshifting GO:0075523 IEA
Subcellular Localization
    nucleolus GO:0005730 IDA
    nucleolus GO:0005730 IMP
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 IMP
    plasma membrane GO:0005886 IEA
    protein-containing complex GO:0032991 IDA
    protein-containing complex GO:0032991 IMP
 Experiment description of studies that identified ERVK-6 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ERVK-6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZBTB32  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ERVK-6 is involved
No pathways found





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