Gene description for Enpep
Gene name glutamyl aminopeptidase
Gene symbol Enpep
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Enpep
ExoCarta ExoCarta_64017
Entrez Gene 64017
UniProt P50123  
 Enpep identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Enpep
Molecular Function
    peptidase activity GO:0008233 ISO
    peptide binding GO:0042277 IDA
    zinc ion binding GO:0008270 IEA
    metalloaminopeptidase activity GO:0070006 ISS
    aminopeptidase activity GO:0004177 ISO
    metallopeptidase activity GO:0008237 ISO
Biological Process
    proteolysis GO:0006508 ISO
    regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 ISS
    cell migration GO:0016477 ISS
    cellular aromatic compound metabolic process GO:0006725 IDA
    angiogenesis GO:0001525 ISO
    cell proliferation GO:0008283 ISS
    glomerulus development GO:0032835 IEA
Subcellular Localization
    cytoplasmic vesicle GO:0031410 ISO
    brush border GO:0005903 ISO
    vesicle membrane GO:0012506 IDA
    integral component of membrane GO:0016021 IEA
    apical plasma membrane GO:0016324 ISO
    external side of plasma membrane GO:0009897 ISO
    apical part of cell GO:0045177 ISO
    extracellular exosome GO:0070062 ISO
    vesicle lumen GO:0031983 IDA
    lysosomal membrane GO:0005765 ISO
 Experiment description of studies that identified Enpep in exosomes
Experiment ID 192
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Enpep
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Enpep is involved
No pathways found

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