Gene description for Enpep
Gene name glutamyl aminopeptidase
Gene symbol Enpep
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Enpep
ExoCarta ExoCarta_64017
Entrez Gene 64017
UniProt P50123  
 Enpep identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Enpep
Molecular Function
    peptidase activity GO:0008233 ISO
    peptide binding GO:0042277 IDA
    zinc ion binding GO:0008270 IEA
    metalloaminopeptidase activity GO:0070006 ISS
    aminopeptidase activity GO:0004177 ISO
    metallopeptidase activity GO:0008237 ISO
Biological Process
    proteolysis GO:0006508 ISO
    regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 ISS
    cell migration GO:0016477 ISS
    cellular aromatic compound metabolic process GO:0006725 IDA
    angiogenesis GO:0001525 ISO
    cell proliferation GO:0008283 ISS
    glomerulus development GO:0032835 IEA
Subcellular Localization
    cytoplasmic vesicle GO:0031410 ISO
    brush border GO:0005903 ISO
    vesicle membrane GO:0012506 IDA
    integral component of membrane GO:0016021 IEA
    apical plasma membrane GO:0016324 ISO
    external side of plasma membrane GO:0009897 ISO
    apical part of cell GO:0045177 ISO
    extracellular exosome GO:0070062 ISO
    vesicle lumen GO:0031983 IDA
    lysosomal membrane GO:0005765 ISO
 Experiment description of studies that identified Enpep in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Enpep
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Enpep is involved
No pathways found





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