Gene description for Slc22a4
Gene name solute carrier family 22 (organic cation/zwitterion transporter), member 4
Gene symbol Slc22a4
Other names/aliases Octn1
Species Rattus norvegicus
 Database cross references - Slc22a4
ExoCarta ExoCarta_64037
Vesiclepedia VP_64037
Entrez Gene 64037
UniProt Q9R141  
 Slc22a4 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Slc22a4
Molecular Function
    acetylcholine transmembrane transporter activity GO:0005277 IEA
    acetylcholine transmembrane transporter activity GO:0005277 ISO
    acetylcholine transmembrane transporter activity GO:0005277 ISS
    ATP binding GO:0005524 IEA
    organic cation transmembrane transporter activity GO:0015101 IDA
    amino acid transmembrane transporter activity GO:0015171 IEA
    amino acid transmembrane transporter activity GO:0015171 ISO
    amino-acid betaine transmembrane transporter activity GO:0015199 IEA
    amino-acid betaine transmembrane transporter activity GO:0015199 ISO
    amino-acid betaine transmembrane transporter activity GO:0015199 ISS
    carnitine transmembrane transporter activity GO:0015226 IEA
    carnitine transmembrane transporter activity GO:0015226 ISO
    symporter activity GO:0015293 IEA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IBA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IDA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IMP
    quaternary ammonium group transmembrane transporter activity GO:0015651 ISO
    PDZ domain binding GO:0030165 IEA
    PDZ domain binding GO:0030165 ISO
Biological Process
    triglyceride metabolic process GO:0006641 IEA
    triglyceride metabolic process GO:0006641 ISO
    sodium ion transport GO:0006814 IEA
    neurotransmitter transport GO:0006836 IEA
    carnitine metabolic process GO:0009437 IEA
    carnitine metabolic process GO:0009437 ISO
    quaternary ammonium group transport GO:0015697 IBA
    quaternary ammonium group transport GO:0015697 IDA
    quaternary ammonium group transport GO:0015697 IMP
    quaternary ammonium group transport GO:0015697 ISO
    quaternary ammonium group transport GO:0015697 ISO
    carnitine transport GO:0015879 ISO
    xenobiotic transport GO:0042908 IEA
    xenobiotic transport GO:0042908 ISO
    amino acid import across plasma membrane GO:0089718 IEA
    amino acid import across plasma membrane GO:0089718 ISO
    acetate ester transport GO:1901374 IEA
    carnitine transmembrane transport GO:1902603 IEA
Subcellular Localization
    mitochondrion GO:0005739 ISO
    basal plasma membrane GO:0009925 IEA
    basal plasma membrane GO:0009925 ISO
    basal plasma membrane GO:0009925 ISS
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    apical plasma membrane GO:0016324 ISS
    mitochondrial membrane GO:0031966 IEA
    mitochondrial membrane GO:0031966 ISO
    mitochondrial membrane GO:0031966 ISS
 Experiment description of studies that identified Slc22a4 in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc22a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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