Gene description for Ctsz
Gene name cathepsin Z
Gene symbol Ctsz
Other names/aliases AI787083
AU019819
CTSX
D2Wsu143e
Species Mus musculus
 Database cross references - Ctsz
ExoCarta ExoCarta_64138
Vesiclepedia VP_64138
Entrez Gene 64138
UniProt Q9WUU7  
 Ctsz identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ctsz
Molecular Function
    carboxypeptidase activity GO:0004180 ISO
    cysteine-type endopeptidase activity GO:0004197 IBA
    cysteine-type carboxypeptidase activity GO:0016807 IEA
Biological Process
    proteolysis GO:0006508 IEA
    proteolysis GO:0006508 ISO
    negative regulation of plasminogen activation GO:0010757 IEA
    negative regulation of plasminogen activation GO:0010757 ISO
    proteolysis involved in protein catabolic process GO:0051603 IBA
    epithelial tube branching involved in lung morphogenesis GO:0060441 IEP
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    lysosome GO:0005764 IBA
    lysosome GO:0005764 IEA
    lysosome GO:0005764 ISO
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum GO:0005783 ISO
    cell cortex GO:0005938 IEA
    cell cortex GO:0005938 ISO
    cell surface GO:0009986 ISO
    growth cone GO:0030426 ISO
    cytoplasmic vesicle GO:0031410 IEA
    cytoplasmic vesicle GO:0031410 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified Ctsz in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ctsz
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atg5  
Affinity Capture-MS Mus musculus
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