Gene description for Pafah1b2
Gene name platelet-activating factor acetylhydrolase 1b, catalytic subunit 2
Gene symbol Pafah1b2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pafah1b2
ExoCarta ExoCarta_64189
Entrez Gene 64189
UniProt O35264  
 Pafah1b2 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Pafah1b2
Molecular Function
    platelet-activating factor acetyltransferase activity GO:0047179 TAS
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IDA
    protein heterodimerization activity GO:0046982 IPI
    1-alkyl-2-acetylglycerophosphocholine esterase activity GO:0003847 IEA
Biological Process
    positive regulation of macroautophagy GO:0016239 ISO
    spermatogenesis GO:0007283 ISO
    brain development GO:0007420 IEP
    lipid catabolic process GO:0016042 IEA
Subcellular Localization
    nucleolus GO:0005730 ISO
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Pafah1b2 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Pafah1b2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pafah1b2 is involved
No pathways found





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