Gene description for Gpx3
Gene name glutathione peroxidase 3
Gene symbol Gpx3
Other names/aliases GPx-3
GPx-P
GSHPx-3
GSHPx-P
Gpxp
Species Rattus norvegicus
 Database cross references - Gpx3
ExoCarta ExoCarta_64317
Entrez Gene 64317
UniProt P23764  
 Gpx3 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Gpx3
Molecular Function
    glutathione peroxidase activity GO:0004602 ISS
    glutathione binding GO:0043295 IDA
    selenium binding GO:0008430 ISS
Biological Process
    response to selenium ion GO:0010269 IEP
    response to organic substance GO:0010033 IEP
    hydrogen peroxide catabolic process GO:0042744 ISO
    oxidation-reduction process GO:0055114 ISO
    protein homotetramerization GO:0051289 ISS
    response to oxidative stress GO:0006979 IEA
    female pregnancy GO:0007565 IEP
    response to corticosterone GO:0051412 IEP
    response to molecule of fungal origin GO:0002238 IEP
    glutathione metabolic process GO:0006749 IDA
    response to drug GO:0042493 IEP
    response to organic cyclic compound GO:0014070 IEP
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISS
 Experiment description of studies that identified Gpx3 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Gpx3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gpx3 is involved
No pathways found





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