Gene description for Ppib
Gene name peptidylprolyl isomerase B
Gene symbol Ppib
Other names/aliases CypB
Scylp
Species Rattus norvegicus
 Database cross references - Ppib
ExoCarta ExoCarta_64367
Entrez Gene 64367
UniProt P24368  
 Ppib identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Ppib
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    protein binding GO:0005515 IPI
    RNA polymerase binding GO:0070063 ISO
    protein complex binding GO:0032403 ISS
    peptide binding GO:0042277 IEA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 ISS
Biological Process
    positive regulation of multicellular organism growth GO:0040018 ISO
    protein peptidyl-prolyl isomerization GO:0000413 ISS
    chaperone-mediated protein folding GO:0061077 ISS
    positive regulation by host of viral process GO:0044794 ISO
    protein stabilization GO:0050821 ISO
    regulation of post-translational protein modification GO:1901873 ISO
    positive regulation by host of viral genome replication GO:0044829 ISO
    bone development GO:0060348 ISO
    nuclear transport GO:0051169 TAS
Subcellular Localization
    nucleus GO:0005634 ISO
    smooth endoplasmic reticulum GO:0005790 IDA
    endoplasmic reticulum chaperone complex GO:0034663 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    focal adhesion GO:0005925 ISO
    extracellular exosome GO:0070062 ISO
    melanosome GO:0042470 IEA
    endoplasmic reticulum lumen GO:0005788 IEA
    macromolecular complex GO:0032991 ISS
    membrane GO:0016020 ISO
    endoplasmic reticulum GO:0005783 ISO
 Experiment description of studies that identified Ppib in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ppib
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ppib is involved
PathwayEvidenceSource
Collagen biosynthesis and modifying enzymes IEA Reactome





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