Gene description for Metap2
Gene name methionyl aminopeptidase 2
Gene symbol Metap2
Other names/aliases Amp2
Mnpep
p67
Species Rattus norvegicus
 Database cross references - Metap2
ExoCarta ExoCarta_64370
Entrez Gene 64370
UniProt P38062  
 Metap2 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Metap2
Molecular Function
    metalloaminopeptidase activity GO:0070006 IEA
    aminopeptidase activity GO:0004177 ISS
    metalloexopeptidase activity GO:0008235 ISS
    poly(A) RNA binding GO:0044822 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    protein initiator methionine removal GO:0070084 IEA
    proteolysis GO:0006508 IEA
    protein processing GO:0016485 ISS
    N-terminal protein amino acid modification GO:0031365 ISS
    peptidyl-methionine modification GO:0018206 ISS
Subcellular Localization
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified Metap2 in exosomes
1
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Metap2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Metap2 is involved
No pathways found





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