Gene description for MMP25
Gene name matrix metallopeptidase 25
Gene symbol MMP25
Other names/aliases MMP-25
MMP20
MMP20A
MMPL1
MT-MMP 6
MT-MMP6
MT6-MMP
MT6MMP
MTMMP6
Species Homo sapiens
 Database cross references - MMP25
ExoCarta ExoCarta_64386
Vesiclepedia VP_64386
Entrez Gene 64386
HGNC 14246
MIM 608482
UniProt Q9NPA2  
 MMP25 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for MMP25
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
    calcium ion binding GO:0005509 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    inflammatory response GO:0006954 NAS
    proteolysis GO:0006508 NAS
    hard palate development GO:0060022 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    proteinaceous extracellular matrix GO:0005578 NAS
    membrane GO:0016020 NAS
    integral component of membrane GO:0016021 IEA
    anchored component of membrane GO:0031225 IEA
 Experiment description of studies that identified MMP25 in exosomes
1
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MMP25
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLU 1191
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which MMP25 is involved
PathwayEvidenceSource
Activation of Matrix Metalloproteinases TAS Reactome





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