Gene description for Aldh1l1
Gene name aldehyde dehydrogenase 1 family, member L1
Gene symbol Aldh1l1
Other names/aliases FDH
Fthfd
Species Rattus norvegicus
 Database cross references - Aldh1l1
ExoCarta ExoCarta_64392
Entrez Gene 64392
UniProt P28037  
 Aldh1l1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Aldh1l1
Molecular Function
    methyltransferase activity GO:0008168 IEA
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 IEA
    aldehyde dehydrogenase [NAD(P)+] activity GO:0004030 IDA
    aldehyde dehydrogenase (NAD) activity GO:0004029 IBA
    formyltetrahydrofolate dehydrogenase activity GO:0016155 TAS
    hydroxymethyl-, formyl- and related transferase activity GO:0016742 IEA
    aldehyde dehydrogenase (NADP+) activity GO:0033721 IDA
    protein complex binding GO:0032403 IDA
Biological Process
    tetrahydrofolate biosynthetic process GO:0046654 TAS
    methylation GO:0032259 IEA
    one-carbon metabolic process GO:0006730 IEA
    10-formyltetrahydrofolate catabolic process GO:0009258 IEA
    biosynthetic process GO:0009058 IEA
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    protein complex GO:0043234 IDA
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Aldh1l1 in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Aldh1l1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aldh1l1 is involved
No pathways found





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