Gene description for Eif2b1
Gene name eukaryotic translation initiation factor 2B, subunit 1 alpha
Gene symbol Eif2b1
Other names/aliases eIF-2a
Species Rattus norvegicus
 Database cross references - Eif2b1
ExoCarta ExoCarta_64514
Entrez Gene 64514
UniProt Q64270  
 Eif2b1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Eif2b1
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 ISS
    GTP binding GO:0005525 IMP
    GDP binding GO:0019003 IDA
    enzyme regulator activity GO:0030234 IMP
    S-methyl-5-thioribose-1-phosphate isomerase activity GO:0046523 IBA
    translation initiation factor activity GO:0003743 TAS
Biological Process
    oligodendrocyte development GO:0014003 ISS
    negative regulation of translational initiation in response to stress GO:0032057 IMP
    response to heat GO:0009408 IDA
    L-methionine biosynthetic process from methylthioadenosine GO:0019509 IBA
    regulation of translation GO:0006417 IMP
    translation GO:0006412 TAS
    response to glucose GO:0009749 IDA
    translational initiation GO:0006413 ISS
    positive regulation of GTPase activity GO:0043547 ISO
    response to peptide hormone GO:0043434 IDA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    eukaryotic translation initiation factor 2B complex GO:0005851 ISS
    eukaryotic translation initiation factor 2 complex GO:0005850 TAS
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Eif2b1 in exosomes
Experiment ID 98
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Eif2b1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Eif2b1 is involved
Recycling of eIF2:GDP IEA Reactome

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