Gene description for Arl3
Gene name ADP-ribosylation factor-like 3
Gene symbol Arl3
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Arl3
ExoCarta ExoCarta_64664
Entrez Gene 64664
UniProt P37996  
 Arl3 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Arl3
Molecular Function
    microtubule binding GO:0008017 ISS
    GTP binding GO:0005525 ISO
    metal ion binding GO:0046872 IEA
    GTPase activity GO:0003924 ISO
    GDP binding GO:0019003 ISO
Biological Process
    small GTPase mediated signal transduction GO:0007264 ISS
    cilium morphogenesis GO:0060271 ISS
    smoothened signaling pathway GO:0007224 ISO
    intraciliary transport GO:0042073 ISO
    protein transport GO:0015031 IEA
    photoreceptor cell development GO:0042461 ISS
    post-Golgi vesicle-mediated transport GO:0006892 ISO
    metabolic process GO:0008152 IEA
    kidney development GO:0001822 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    spindle microtubule GO:0005876 ISS
    cilium GO:0005929 ISO
    cell GO:0005623 ISO
    Golgi membrane GO:0000139 IEA
    primary cilium GO:0072372 ISS
    intracellular GO:0005622 ISO
    Golgi apparatus GO:0005794 ISS
    centrosome GO:0005813 ISS
    photoreceptor connecting cilium GO:0032391 ISS
    extracellular exosome GO:0070062 ISO
    midbody GO:0030496 ISS
    cytoplasmic microtubule GO:0005881 ISS
 Experiment description of studies that identified Arl3 in exosomes
1
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Arl3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Arl3 is involved
PathwayEvidenceSource
Trafficking of myristoylated proteins to the cilium IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here