Gene description for Sfxn3
Gene name sideroflexin 3
Gene symbol Sfxn3
Other names/aliases TCC
Species Rattus norvegicus
 Database cross references - Sfxn3
ExoCarta ExoCarta_65042
Vesiclepedia VP_65042
Entrez Gene 65042
UniProt Q9JHY2  
 Sfxn3 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Sfxn3
Molecular Function
    tricarboxylate secondary active transmembrane transporter activity GO:0005371 TAS
    monoatomic ion transmembrane transporter activity GO:0015075 IEA
    L-serine transmembrane transporter activity GO:0015194 IEA
    L-serine transmembrane transporter activity GO:0015194 ISO
    L-serine transmembrane transporter activity GO:0015194 ISS
    transmembrane transporter activity GO:0022857 IBA
Biological Process
    one-carbon metabolic process GO:0006730 IEA
    one-carbon metabolic process GO:0006730 ISO
    one-carbon metabolic process GO:0006730 ISS
    amino acid transport GO:0006865 IEA
    biological_process GO:0008150 ND
    L-serine transport GO:0015825 IEA
    monoatomic ion transmembrane transport GO:0034220 IEA
    serine import into mitochondrion GO:0140300 IBA
    serine import into mitochondrion GO:0140300 IEA
    serine import into mitochondrion GO:0140300 ISO
    serine import into mitochondrion GO:0140300 ISS
    mitochondrial transmembrane transport GO:1990542 ISO
    mitochondrial transmembrane transport GO:1990542 ISS
Subcellular Localization
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 IBA
    mitochondrial membrane GO:0031966 IDA
    mitochondrial membrane GO:0031966 IEA
 Experiment description of studies that identified Sfxn3 in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Sfxn3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Dao  
Affinity Capture-MS Rattus norvegicus
2 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Sfxn3 is involved
No pathways found





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