ExoCarta: Gene summary

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Gene description for Adrm1
Gene name	adhesion regulating molecule 1
Gene symbol	Adrm1
Other names/aliases	Gp110
Species	Rattus norvegicus
Database cross references - Adrm1
ExoCarta	ExoCarta_65138
Vesiclepedia	VP_65138
Entrez Gene	65138
UniProt	Q9JMB5
Adrm1 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Adrm1

Molecular Function
	protease binding	GO:0002020	IEA
	protease binding	GO:0002020	ISO
	endopeptidase activator activity	GO:0061133	IBA
	endopeptidase activator activity	GO:0061133	IEA
	endopeptidase activator activity	GO:0061133	ISO
	endopeptidase activator activity	GO:0061133	ISS
	proteasome binding	GO:0070628	IBA
	proteasome binding	GO:0070628	IEA
	proteasome binding	GO:0070628	ISO
	molecular function inhibitor activity	GO:0140678	ISO
Biological Process
	ovarian follicle development	GO:0001541	ISO
	transcription elongation by RNA polymerase II	GO:0006368	IEA
	transcription elongation by RNA polymerase II	GO:0006368	ISO
	spermatid development	GO:0007286	ISO
	regulation of T cell differentiation in thymus	GO:0033081	ISO
	follicle-stimulating hormone signaling pathway	GO:0042699	ISO
	proteasome assembly	GO:0043248	IEA
	proteasome assembly	GO:0043248	ISO
	proteasome assembly	GO:0043248	ISS
	oogenesis	GO:0048477	ISO
	thymus development	GO:0048538	ISO
	Sertoli cell development	GO:0060009	ISO
	positive regulation of growth hormone receptor signaling pathway	GO:0060399	ISO
	adipose tissue development	GO:0060612	ISO
	seminiferous tubule development	GO:0072520	ISO
Subcellular Localization
	proteasome complex	GO:0000502	IEA
	proteasome complex	GO:0000502	ISO
	proteasome complex	GO:0000502	ISS
	nucleus	GO:0005634	IEA
	nucleoplasm	GO:0005654	IEA
	nucleoplasm	GO:0005654	ISO
	cytoplasm	GO:0005737	IEA
	cytosol	GO:0005829	IEA
	cytosol	GO:0005829	ISO
	plasma membrane	GO:0005886	IEA
	plasma membrane	GO:0005886	ISO
	proteasome regulatory particle, lid subcomplex	GO:0008541	IBA

Experiment description of studies that identified Adrm1 in sEVs

Experiment ID

MISEV standards
✔ EM	Biophysical techniques
✔ TSG101\|HSP90\|HSC70\|MHCI	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry [Orbitrap]

PubMed ID

21828046

Organism

Rattus norvegicus

Experiment description

The proteo-lipidic composition of exosomes changes during reticulocyte maturation.

Authors

"Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."

Journal name

JBC

Publication year

2011

Sample

Reticulocytes

Sample name

Reticulocytes - D7 Rep 1

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient

Flotation density

1.13-1.25 g/mL

Molecules identified in the study

Protein
Lipids

Methods used in the study

Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting

Protein-protein interactions for Adrm1

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

Rad23b

Affinity Capture-MS

Rattus norvegicus

View the network

Pathways in which Adrm1 is involved

Pathway	Evidence	Source
ABC-family proteins mediated transport	IEA	Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	IEA	Reactome
Activation of NF-kappaB in B cells	IEA	Reactome
Adaptive Immune System	IEA	Reactome
Antigen processing-Cross presentation	IEA	Reactome
Antigen processing: Ubiquitination & Proteasome degradation	IEA	Reactome
APC/C-mediated degradation of cell cycle proteins	IEA	Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins	IEA	Reactome
APC/C:Cdc20 mediated degradation of Securin	IEA	Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	IEA	Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	IEA	Reactome
Assembly of the pre-replicative complex	IEA	Reactome
Asymmetric localization of PCP proteins	IEA	Reactome
AUF1 (hnRNP D0) binds and destabilizes mRNA	IEA	Reactome
Autodegradation of Cdh1 by Cdh1:APC/C	IEA	Reactome
Autodegradation of the E3 ubiquitin ligase COP1	IEA	Reactome
Beta-catenin independent WNT signaling	IEA	Reactome
C-type lectin receptors (CLRs)	IEA	Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	IEA	Reactome
CDK-mediated phosphorylation and removal of Cdc6	IEA	Reactome
Cell Cycle	IEA	Reactome
Cell Cycle Checkpoints	IEA	Reactome
Cell Cycle, Mitotic	IEA	Reactome
Cellular response to chemical stress	IEA	Reactome
Cellular response to hypoxia	IEA	Reactome
Cellular responses to stimuli	IEA	Reactome
Cellular responses to stress	IEA	Reactome
Class I MHC mediated antigen processing & presentation	IEA	Reactome
CLEC7A (Dectin-1) signaling	IEA	Reactome
Cross-presentation of soluble exogenous antigens (endosomes)	IEA	Reactome
Cyclin A:Cdk2-associated events at S phase entry	IEA	Reactome
Cyclin E associated events during G1/S transition	IEA	Reactome
Cytokine Signaling in Immune system	IEA	Reactome
Dectin-1 mediated noncanonical NF-kB signaling	IEA	Reactome
Degradation of AXIN	IEA	Reactome
Degradation of beta-catenin by the destruction complex	IEA	Reactome
Degradation of DVL	IEA	Reactome
Degradation of GLI1 by the proteasome	IEA	Reactome
Deubiquitination	IEA	Reactome
DNA Replication	IEA	Reactome
DNA Replication Pre-Initiation	IEA	Reactome
Downstream signaling events of B Cell Receptor (BCR)	IEA	Reactome
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	IEA	Reactome
G1/S DNA Damage Checkpoints	IEA	Reactome
G1/S Transition	IEA	Reactome
G2/M Checkpoints	IEA	Reactome
G2/M Transition	IEA	Reactome
Gene expression (Transcription)	IEA	Reactome
Generic Transcription Pathway	IEA	Reactome
GLI3 is processed to GLI3R by the proteasome	IEA	Reactome
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	IEA	Reactome
Hedgehog 'off' state	IEA	Reactome
Hedgehog 'on' state	IEA	Reactome
Hedgehog ligand biogenesis	IEA	Reactome
Immune System	IEA	Reactome
Innate Immune System	IEA	Reactome
Intracellular signaling by second messengers	IEA	Reactome
KEAP1-NFE2L2 pathway	IEA	Reactome
M Phase	IEA	Reactome
MAPK family signaling cascades	IEA	Reactome
MAPK1/MAPK3 signaling	IEA	Reactome
MAPK6/MAPK4 signaling	IEA	Reactome
Metabolism	IEA	Reactome
Metabolism of amino acids and derivatives	IEA	Reactome
Metabolism of polyamines	IEA	Reactome
Metabolism of proteins	IEA	Reactome
Metabolism of RNA	IEA	Reactome
Mitotic Anaphase	IEA	Reactome
Mitotic G1 phase and G1/S transition	IEA	Reactome
Mitotic G2-G2/M phases	IEA	Reactome
Mitotic Metaphase and Anaphase	IEA	Reactome
Neddylation	IEA	Reactome
NIK-->noncanonical NF-kB signaling	IEA	Reactome
Nuclear events mediated by NFE2L2	IEA	Reactome
Orc1 removal from chromatin	IEA	Reactome
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	IEA	Reactome
p53-Dependent G1 DNA Damage Response	IEA	Reactome
p53-Dependent G1/S DNA damage checkpoint	IEA	Reactome
p53-Independent DNA Damage Response	IEA	Reactome
p53-Independent G1/S DNA damage checkpoint	IEA	Reactome
PCP/CE pathway	IEA	Reactome
PIP3 activates AKT signaling	IEA	Reactome
Post-translational protein modification	IEA	Reactome
Proteasome assembly	IEA	Reactome
PTEN Regulation	IEA	Reactome
RAF/MAP kinase cascade	IEA	Reactome
Regulation of APC/C activators between G1/S and early anaphase	IEA	Reactome
Regulation of mitotic cell cycle	IEA	Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements	IEA	Reactome
Regulation of ornithine decarboxylase (ODC)	IEA	Reactome
Regulation of PTEN stability and activity	IEA	Reactome
Regulation of RAS by GAPs	IEA	Reactome
Regulation of RUNX3 expression and activity	IEA	Reactome
RNA Polymerase II Transcription	IEA	Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs	IEA	Reactome
S Phase	IEA	Reactome
SCF(Skp2)-mediated degradation of p27/p21	IEA	Reactome
SCF-beta-TrCP mediated degradation of Emi1	IEA	Reactome
Separation of Sister Chromatids	IEA	Reactome
Signal Transduction	IEA	Reactome
Signaling by Hedgehog	IEA	Reactome
Signaling by the B Cell Receptor (BCR)	IEA	Reactome
Signaling by WNT	IEA	Reactome
Stabilization of p53	IEA	Reactome
Switching of origins to a post-replicative state	IEA	Reactome
Synthesis of DNA	IEA	Reactome
TCF dependent signaling in response to WNT	IEA	Reactome
The role of GTSE1 in G2/M progression after G2 checkpoint	IEA	Reactome
TNFR2 non-canonical NF-kB pathway	IEA	Reactome
Transcriptional regulation by RUNX1	IEA	Reactome
Transcriptional regulation by RUNX3	IEA	Reactome
Transport of small molecules	IEA	Reactome
Ub-specific processing proteases	IEA	Reactome
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	IEA	Reactome
Ubiquitin-dependent degradation of Cyclin D	IEA	Reactome
UCH proteinases	IEA	Reactome

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