Gene description for Pdzk1
Gene name PDZ domain containing 1
Gene symbol Pdzk1
Other names/aliases Clamp
Species Rattus norvegicus
 Database cross references - Pdzk1
ExoCarta ExoCarta_65144
Entrez Gene 65144
UniProt Q9JJ40  
 Pdzk1 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Pdzk1
Molecular Function
    PDZ domain binding GO:0030165 ISO
    protein binding GO:0005515 IPI
    protein complex binding GO:0032403 IPI
    scavenger receptor binding GO:0005124 IDA
Biological Process
    regulation of anion transport GO:0044070 ISS
    positive regulation of ion transmembrane transport GO:0034767 ISO
    intracellular transport GO:0046907 NAS
    carnitine transport GO:0015879 ISO
    positive regulation of protein targeting to membrane GO:0090314 ISS
    cholesterol transport GO:0030301 NAS
    transport GO:0006810 ISO
    establishment of protein localization to plasma membrane GO:0090002 ISO
Subcellular Localization
    brush border membrane GO:0031526 ISS
    apical plasma membrane GO:0016324 IDA
    extracellular exosome GO:0070062 ISO
    microvillus membrane GO:0031528 IDA
    plasma membrane GO:0005886 ISS
    cytoplasm GO:0005737 IEA
    membrane raft GO:0045121 IDA
 Experiment description of studies that identified Pdzk1 in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pdzk1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pdzk1 is involved
No pathways found





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