Gene description for Hrsp12
Gene name heat-responsive protein 12
Gene symbol Hrsp12
Other names/aliases PSP1
Psp
Species Rattus norvegicus
 Database cross references - Hrsp12
ExoCarta ExoCarta_65151
Vesiclepedia VP_65151
Entrez Gene 65151
UniProt P52759  
 Hrsp12 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Hrsp12
Molecular Function
    mRNA binding GO:0003729 IEA
    mRNA binding GO:0003729 ISO
    mRNA binding GO:0003729 ISS
    RNA endonuclease activity, producing 3'-phosphomonoesters GO:0016892 IDA
    deaminase activity GO:0019239 IBA
    long-chain fatty acid binding GO:0036041 IDA
    identical protein binding GO:0042802 IPI
    cation binding GO:0043169 IDA
    transition metal ion binding GO:0046914 IDA
    2-iminobutanoate deaminase activity GO:0120242 IEA
    2-iminopropanoate deaminase activity GO:0120243 IEA
Biological Process
    kidney development GO:0001822 IEP
    mRNA catabolic process GO:0006402 IBA
    mRNA catabolic process GO:0006402 IEA
    mRNA catabolic process GO:0006402 ISO
    mRNA catabolic process GO:0006402 ISS
    lipid metabolic process GO:0006629 IEA
    negative regulation of translation GO:0017148 IBA
    negative regulation of translation GO:0017148 IDA
    lung development GO:0030324 IEP
    response to lipid GO:0033993 IEP
    negative regulation of epithelial cell proliferation GO:0050680 IMP
    mRNA destabilization GO:0061157 IEA
    mRNA destabilization GO:0061157 ISO
    mRNA destabilization GO:0061157 ISS
    G1 to G0 transition GO:0070314 IEP
    response to salt GO:1902074 IEP
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IEA
    mitochondrial matrix GO:0005759 IDA
    peroxisome GO:0005777 IDA
    peroxisome GO:0005777 IEA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Hrsp12 in exosomes
1
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Hrsp12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hrsp12 is involved
PathwayEvidenceSource
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Threonine catabolism IEA Reactome





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