Gene description for Hrsp12
Gene name heat-responsive protein 12
Gene symbol Hrsp12
Other names/aliases PSP1
Psp
Species Rattus norvegicus
 Database cross references - Hrsp12
ExoCarta ExoCarta_65151
Entrez Gene 65151
UniProt P52759  
 Hrsp12 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Hrsp12
Molecular Function
    deaminase activity GO:0019239 IEA
    ion binding GO:0043167 IDA
    xenon atom binding GO:1904013 IPI
    poly(A) RNA binding GO:0044822 ISO
    endoribonuclease activity, producing 3'-phosphomonoesters GO:0016892 IDA
    platinum binding GO:1904012 IPI
    long-chain fatty acid binding GO:0036041 IDA
    protein homodimerization activity GO:0042803 IDA
    transition metal ion binding GO:0046914 IDA
Biological Process
    negative regulation of translation GO:0017148 IDA
    response to salt GO:1902074 IEP
    response to lipid GO:0033993 IEP
    RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 IDA
    lung development GO:0030324 IEP
    kidney development GO:0001822 IEP
    brain development GO:0007420 IEP
    G1 to G0 transition GO:0070314 IEP
    negative regulation of epithelial cell proliferation GO:0050680 IMP
Subcellular Localization
    mitochondrion GO:0005739 ISO
    extracellular exosome GO:0070062 ISO
    cytosol GO:0005829 IDA
    peroxisome GO:0005777 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Hrsp12 in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Hrsp12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hrsp12 is involved
No pathways found





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