Gene description for Myo1c
Gene name myosin IC
Gene symbol Myo1c
Other names/aliases Myr2
Species Rattus norvegicus
 Database cross references - Myo1c
ExoCarta ExoCarta_65261
Vesiclepedia VP_65261
Entrez Gene 65261
UniProt Q63355  
 Myo1c identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Myo1c
Molecular Function
    microfilament motor activity GO:0000146 IBA
    microfilament motor activity GO:0000146 IDA
    microfilament motor activity GO:0000146 ISO
    cytoskeletal motor activity GO:0003774 IEA
    actin binding GO:0003779 IEA
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    calmodulin binding GO:0005516 IDA
    ATP binding GO:0005524 IEA
    small GTPase binding GO:0031267 IEA
    small GTPase binding GO:0031267 ISO
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 IDA
Biological Process
    protein targeting to membrane GO:0006612 IEA
    protein targeting to membrane GO:0006612 ISO
    endocytosis GO:0006897 IBA
    actin filament organization GO:0007015 IBA
    protein transport GO:0015031 IEA
    actin filament-based movement GO:0030048 IBA
    vesicle transport along actin filament GO:0030050 IEA
    vesicle transport along actin filament GO:0030050 ISO
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of actin filament polymerization GO:0030838 IMP
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 ISO
    positive regulation of transcription by RNA polymerase III GO:0045945 ISO
    cellular response to type II interferon GO:0071346 IEA
    cellular response to type II interferon GO:0071346 ISO
    positive regulation of protein targeting to membrane GO:0090314 IEA
    positive regulation of protein targeting to membrane GO:0090314 ISO
    positive regulation of cellular response to insulin stimulus GO:1900078 IEA
    positive regulation of cellular response to insulin stimulus GO:1900078 IMP
    positive regulation of cellular response to insulin stimulus GO:1900078 ISO
    regulation of bicellular tight junction assembly GO:2000810 IEA
    regulation of bicellular tight junction assembly GO:2000810 ISO
Subcellular Localization
    stress fiber GO:0001725 ISO
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    microvillus GO:0005902 IBA
    microvillus GO:0005902 IEA
    microvillus GO:0005902 ISO
    brush border GO:0005903 IEA
    brush border GO:0005903 ISO
    cell cortex GO:0005938 IEA
    basal plasma membrane GO:0009925 IEA
    basal plasma membrane GO:0009925 ISO
    actin cytoskeleton GO:0015629 IBA
    membrane GO:0016020 ISO
    lateral plasma membrane GO:0016328 IEA
    lateral plasma membrane GO:0016328 ISO
    myosin complex GO:0016459 IEA
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
    cytoplasmic vesicle membrane GO:0030659 IEA
    cytoplasmic vesicle membrane GO:0030659 ISO
    filamentous actin GO:0031941 IEA
    filamentous actin GO:0031941 ISO
    stereocilium GO:0032420 ISO
    stereocilium bundle GO:0032421 IDA
    ruffle membrane GO:0032587 IDA
    membrane raft GO:0045121 IDA
    membrane raft GO:0045121 IEA
    membrane raft GO:0045121 ISO
    phagocytic vesicle GO:0045335 IEA
    phagocytic vesicle GO:0045335 ISO
    stereocilium membrane GO:0060171 IEA
    B-WICH complex GO:0110016 ISO
 Experiment description of studies that identified Myo1c in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Myo1c
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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