Gene description for Setd6
Gene name SET domain containing 6
Gene symbol Setd6
Other names/aliases 0610039J04Rik
3110004G14Rik
AI413388
C76402
Species Mus musculus
 Database cross references - Setd6
ExoCarta ExoCarta_66083
Vesiclepedia VP_66083
Entrez Gene 66083
UniProt Q9CWY3  
 Setd6 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Setd6
Molecular Function
    protein binding GO:0005515 IPI
    protein-lysine N-methyltransferase activity GO:0016279 IBA
    protein-lysine N-methyltransferase activity GO:0016279 ISO
    protein-lysine N-methyltransferase activity GO:0016279 ISS
    NF-kappaB binding GO:0051059 IEA
    NF-kappaB binding GO:0051059 ISO
    S-adenosyl-L-methionine binding GO:1904047 ISO
    S-adenosyl-L-methionine binding GO:1904047 ISS
Biological Process
    peptidyl-lysine monomethylation GO:0018026 ISO
    peptidyl-lysine monomethylation GO:0018026 ISS
    stem cell population maintenance GO:0019827 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISO
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISS
    stem cell differentiation GO:0048863 IDA
    regulation of inflammatory response GO:0050727 ISO
    regulation of inflammatory response GO:0050727 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Setd6 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Setd6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Setd6 is involved
PathwayEvidenceSource
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
PKMTs methylate histone lysines IEA Reactome





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