Gene description for Setd6
Gene name SET domain containing 6
Gene symbol Setd6
Other names/aliases 0610039J04Rik
3110004G14Rik
AI413388
C76402
Species Mus musculus
 Database cross references - Setd6
ExoCarta ExoCarta_66083
Entrez Gene 66083
UniProt Q9CWY3  
 Setd6 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Setd6
Molecular Function
    rRNA (cytosine-N4-)-methyltransferase activity GO:0071424 IEA
    methylarsonite methyltransferase activity GO:0030792 IEA
    tRNA (cytosine-2'-O-)-methyltransferase activity GO:0052666 IEA
    2-phytyl-1,4-naphthoquinone methyltransferase activity GO:0052624 IEA
    protein methyltransferase activity GO:0008276 IEA
    C-methyltransferase activity GO:0008169 IEA
    tRNA (adenine-57, 58-N(1)-) methyltransferase activity GO:0043827 IEA
    tRNA (guanine) methyltransferase activity GO:0016423 IEA
    protein-arginine N-methyltransferase activity GO:0016274 IEA
    cobalt-precorrin-6B C5-methyltransferase activity GO:0043776 IEA
    N-methyltransferase activity GO:0008170 IEA
    tRNA (adenine-N1-)-methyltransferase activity GO:0016429 IEA
    tRNA (guanine-N2-)-methyltransferase activity GO:0004809 IEA
    cobalt-precorrin-3 C17-methyltransferase activity GO:0043782 IEA
    phosphomethylethanolamine N-methyltransferase activity GO:0052667 IEA
    methyltransferase activity GO:0008168 IEA
    demethylmenaquinone methyltransferase activity GO:0043770 IEA
    selenocysteine methyltransferase activity GO:0016205 IEA
    protein C-terminal leucine carboxyl O-methyltransferase activity GO:0018423 IEA
    2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity GO:0008425 IEA
    rRNA (cytosine) methyltransferase activity GO:0016434 IEA
    tRNA methyltransferase activity GO:0008175 IEA
    methylamine-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043833 IEA
    4,5-dihydroxybenzo(a)pyrene methyltransferase activity GO:0034807 IEA
    lysine N-methyltransferase activity GO:0016278 IEA
    O-methyltransferase activity GO:0008171 IEA
    arginine N-methyltransferase activity GO:0016273 IEA
    trimethylamine methyltransferase activity GO:0043834 IEA
    dimethylamine methyltransferase activity GO:0043791 IEA
    protein C-terminal carboxyl O-methyltransferase activity GO:0003880 IEA
    mRNA methyltransferase activity GO:0008174 IEA
    dimethylarsinite methyltransferase activity GO:0034541 IEA
    rRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179 IEA
    rRNA (cytosine-C5-)-methyltransferase activity GO:0009383 IEA
    rRNA (adenine-N6-)-methyltransferase activity GO:0008988 IEA
    hydroxyneurosporene-O-methyltransferase activity GO:0043803 IEA
    tRNA (uracil-2'-O-)-methyltransferase activity GO:0052665 IEA
    rRNA methyltransferase activity GO:0008649 IEA
    cobalt-precorrin-7 C15-methyltransferase activity GO:0043777 IEA
    NF-kappaB binding GO:0051059 ISO
    1-hydroxy-6-methoxypyrene methyltransferase activity GO:0034933 IEA
    transferase activity GO:0016740 IEA
    DNA-methyltransferase activity GO:0009008 IEA
    1-phenanthrol methyltransferase activity GO:0018707 IEA
    RNA methyltransferase activity GO:0008173 IEA
    rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 IEA
    rRNA (uridine) methyltransferase activity GO:0016436 IEA
    trihydroxyferuloyl spermidine O-methyltransferase activity GO:0080012 IEA
    protein-lysine N-methyltransferase activity GO:0016279 ISO
    S-methyltransferase activity GO:0008172 IEA
    rRNA (guanine) methyltransferase activity GO:0016435 IEA
    tRNA (cytosine-5-)-methyltransferase activity GO:0016428 IEA
    protein-arginine N5-methyltransferase activity GO:0019702 IEA
    tRNA (guanine-N1-)-methyltransferase activity GO:0009019 IEA
    rRNA (cytosine-2'-O-)-methyltransferase activity GO:0070677 IEA
    tRNA (cytosine-3-)-methyltransferase activity GO:0052735 IEA
    tRNA (cytosine) methyltransferase activity GO:0016427 IEA
    tRNA (adenine) methyltransferase activity GO:0016426 IEA
    monomethylamine methyltransferase activity GO:0043852 IEA
    rRNA (adenine) methyltransferase activity GO:0016433 IEA
    1-hydroxypyrene methyltransferase activity GO:0034931 IEA
    tRNA (uracil) methyltransferase activity GO:0016300 IEA
    methanol-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043851 IEA
    P-methyltransferase activity GO:0051994 IEA
    cobalt-precorrin-5B C1-methyltransferase activity GO:0043780 IEA
    Se-methyltransferase activity GO:0051995 IEA
Biological Process
    peptidyl-lysine monomethylation GO:0018026 ISO
    regulation of inflammatory response GO:0050727 ISO
    methylation GO:0032259 IEA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Setd6 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Setd6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Setd6 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here