Gene description for Cks2
Gene name CDC28 protein kinase regulatory subunit 2
Gene symbol Cks2
Other names/aliases 1110038L14Rik
CKSHS2
Species Mus musculus
 Database cross references - Cks2
ExoCarta ExoCarta_66197
Vesiclepedia VP_66197
Entrez Gene 66197
UniProt P56390  
 Cks2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cks2
Molecular Function
    chromatin binding GO:0003682 IDA
    cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 IEA
    protein kinase binding GO:0019901 IBA
    histone binding GO:0042393 IBA
    ubiquitin binding GO:0043130 IBA
    cyclin-dependent protein serine/threonine kinase activator activity GO:0061575 IBA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IGI
    meiosis I GO:0007127 IMP
    regulation of mitotic cell cycle GO:0007346 IBA
    embryo development GO:0009790 IGI
    mitotic cell cycle phase transition GO:0044772 IGI
    fibroblast proliferation GO:0048144 IGI
    cell division GO:0051301 IEA
Subcellular Localization
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 IBA
    SCF ubiquitin ligase complex GO:0019005 IBA
 Experiment description of studies that identified Cks2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cks2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cks2 is involved
No pathways found





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