Gene description for Sec61b
Gene name Sec61 beta subunit
Gene symbol Sec61b
Other names/aliases 1190006C12Rik
AI326121
AW122942
Species Mus musculus
 Database cross references - Sec61b
ExoCarta ExoCarta_66212
Entrez Gene 66212
UniProt Q9CQS8  
 Sec61b identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Sec61b
Molecular Function
    ribosome binding GO:0043022 IDA
    poly(A) RNA binding GO:0044822 ISO
    epidermal growth factor binding GO:0048408 ISO
Biological Process
    retrograde protein transport, ER to cytosol GO:0030970 ISO
    protein transport GO:0015031 IEA
    transport GO:0006810 IEA
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 ISO
    protein import into nucleus, translocation GO:0000060 ISO
    intracellular protein transport GO:0006886 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    Sec61 translocon complex GO:0005784 IEA
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Sec61b in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Sec61b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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