Gene description for Lamtor1
Gene name late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Gene symbol Lamtor1
Other names/aliases 2400001E08Rik
Pdro
p18
Species Mus musculus
 Database cross references - Lamtor1
ExoCarta ExoCarta_66508
Entrez Gene 66508
UniProt Q9CQ22  
 Lamtor1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Lamtor1
Molecular Function
    protein complex scaffold GO:0032947 ISO
    guanyl-nucleotide exchange factor activity GO:0005085 ISO
    protein binding GO:0005515 IPI
Biological Process
    regulation of cholesterol esterification GO:0010872 ISO
    regulation of receptor recycling GO:0001919 IMP
    lysosome organization GO:0007040 IMP
    cellular protein localization GO:0034613 ISO
    cellular response to amino acid stimulus GO:0071230 ISO
    cell growth GO:0016049 ISO
    cholesterol homeostasis GO:0042632 ISO
    positive regulation of MAPK cascade GO:0043410 IMP
    endosome organization GO:0007032 IMP
    positive regulation of TOR signaling GO:0032008 ISO
    positive regulation of GTPase activity GO:0043547 ISO
    regulation of cholesterol efflux GO:0010874 ISO
    regulation of cholesterol import GO:0060620 ISO
    lysosome localization GO:0032418 IMP
    endosome localization GO:0032439 IMP
Subcellular Localization
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 ISO
    lysosome GO:0005764 ISO
    late endosome membrane GO:0031902 ISO
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 IEA
    Ragulator complex GO:0071986 ISO
    membrane raft GO:0045121 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    endosome GO:0005768 IEA
 Experiment description of studies that identified Lamtor1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Lamtor1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lamtor1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here