Gene description for Cmpk1
Gene name cytidine monophosphate (UMP-CMP) kinase 1
Gene symbol Cmpk1
Other names/aliases 0610011D08Rik
CK
Cmpk
UMP-CMPk
Species Mus musculus
 Database cross references - Cmpk1
ExoCarta ExoCarta_66588
Vesiclepedia VP_66588
Entrez Gene 66588
UniProt Q9DBP5  
 Cmpk1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Pancreatic cells 19351151    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cmpk1
Molecular Function
    UMP kinase activity GO:0033862 ISO
    nucleobase-containing compound kinase activity GO:0019205 IEA
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    kinase activity GO:0016301 IEA
    cytidylate kinase activity GO:0004127 ISO
    transferase activity GO:0016740 IEA
    nucleoside diphosphate kinase activity GO:0004550 ISO
    uridylate kinase activity GO:0009041 IEA
Biological Process
    dUDP biosynthetic process GO:0006227 ISO
    nucleoside diphosphate phosphorylation GO:0006165 ISO
    dCDP biosynthetic process GO:0006240 ISO
    UDP biosynthetic process GO:0006225 ISO
    nucleoside triphosphate biosynthetic process GO:0009142 ISO
    nucleobase-containing compound metabolic process GO:0006139 IEA
    'de novo' pyrimidine nucleobase biosynthetic process GO:0006207 IEA
    pyrimidine nucleotide biosynthetic process GO:0006221 IEA
    phosphorylation GO:0016310 IEA
    CDP biosynthetic process GO:0046705 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleolus GO:0005730 ISO
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Cmpk1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 188
MISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cmpk1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cmpk1 is involved
PathwayEvidenceSource
Synthesis and interconversion of nucleotide di- and triphosphates IEA Reactome





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