Gene description for Actr2
Gene name ARP2 actin-related protein 2
Gene symbol Actr2
Other names/aliases 4921510D23Rik
AA409782
Arp2
D6Ertd746e
Species Mus musculus
 Database cross references - Actr2
ExoCarta ExoCarta_66713
Entrez Gene 66713
UniProt P61161  
 Actr2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Actr2
Molecular Function
    actin filament binding GO:0051015 ISO
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    actin binding GO:0003779 IEA
    structural constituent of cytoskeleton GO:0005200 ISO
Biological Process
    establishment or maintenance of cell polarity GO:0007163 IGI
    asymmetric cell division GO:0008356 IGI
    cilium assembly GO:0042384 ISO
    actin cytoskeleton organization GO:0030036 IMP
    meiotic cell cycle GO:0051321 IGI
    meiotic chromosome movement towards spindle pole GO:0016344 IGI
    spindle localization GO:0051653 IGI
    meiotic cytokinesis GO:0033206 IGI
    Arp2/3 complex-mediated actin nucleation GO:0034314 ISO
    actin filament organization GO:0007015 IEA
    cytoplasmic transport GO:0016482 IMP
Subcellular Localization
    intracellular GO:0005622 IMP
    Arp2/3 protein complex GO:0005885 ISO
    cytoskeleton GO:0005856 IEA
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 ISO
    focal adhesion GO:0005925 ISO
    actin cap GO:0030478 IDA
    cell cortex GO:0005938 IDA
    cell GO:0005623 IGI
    cell projection GO:0042995 IEA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Actr2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Actr2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here