Gene description for SPP2
Gene name secreted phosphoprotein 2, 24kDa
Gene symbol SPP2
Other names/aliases SPP-24
SPP24
Species Homo sapiens
 Database cross references - SPP2
ExoCarta ExoCarta_6694
Entrez Gene 6694
HGNC 11256
MIM 602637
UniProt Q13103  
 SPP2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for SPP2
Molecular Function
    endopeptidase inhibitor activity GO:0004866 TAS
Biological Process
    protein complex assembly GO:0006461 IEA
    negative regulation of endopeptidase activity GO:0010951 TAS
    skeletal system development GO:0001501 TAS
    bone remodeling GO:0046849 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    protein complex GO:0043234 IEA
 Experiment description of studies that identified SPP2 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for SPP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SPP2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here