Gene description for Tmem206
Gene name transmembrane protein 206
Gene symbol Tmem206
Other names/aliases 2310028N02Rik
AI118576
Species Mus musculus
 Database cross references - Tmem206
ExoCarta ExoCarta_66950
Vesiclepedia VP_66950
Entrez Gene 66950
UniProt Q9D771  
 Tmem206 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tmem206
Molecular Function
    pH-gated chloride channel activity GO:0061797 IMP
    pH-gated chloride channel activity GO:0061797 ISO
Biological Process
    chloride transport GO:0006821 IMP
    chloride transport GO:0006821 ISO
    chloride transmembrane transport GO:1902476 IEA
Subcellular Localization
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    chloride channel complex GO:0034707 IEA
 Experiment description of studies that identified Tmem206 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tmem206
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tmem206 is involved
No pathways found





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