Gene description for Edem3
Gene name ER degradation enhancer, mannosidase alpha-like 3
Gene symbol Edem3
Other names/aliases 2310050N11Rik
Species Mus musculus
 Database cross references - Edem3
ExoCarta ExoCarta_66967
Vesiclepedia VP_66967
Entrez Gene 66967
UniProt Q2HXL6  
 Edem3 identified in sEVs derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Edem3
Molecular Function
    mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571 IBA
    mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571 IDA
    mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571 ISO
    calcium ion binding GO:0005509 IEA
Biological Process
    carbohydrate metabolic process GO:0005975 IEA
    mannoprotein catabolic process GO:0006058 IBA
    mannoprotein catabolic process GO:0006058 IDA
    mannoprotein catabolic process GO:0006058 ISO
    protein glycosylation GO:0006486 IEA
    glycoprotein catabolic process GO:0006516 IDA
    response to unfolded protein GO:0006986 IEA
    endoplasmic reticulum unfolded protein response GO:0030968 IBA
    ERAD pathway GO:0036503 IDA
    ERAD pathway GO:0036503 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA
    ubiquitin-dependent glycoprotein ERAD pathway GO:0097466 IBA
    endoplasmic reticulum mannose trimming GO:1904380 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum lumen GO:0005788 IDA
    membrane GO:0016020 IEA
    endoplasmic reticulum quality control compartment GO:0044322 IEA
 Experiment description of studies that identified Edem3 in sEVs
1
Experiment ID 263
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Edem3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Edem3 is involved
No pathways found





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