Gene description for Edem3
Gene name ER degradation enhancer, mannosidase alpha-like 3
Gene symbol Edem3
Other names/aliases 2310050N11Rik
Species Mus musculus
 Database cross references - Edem3
ExoCarta ExoCarta_66967
Entrez Gene 66967
UniProt Q2HXL6  
 Edem3 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Edem3
Molecular Function
    fucosidase activity GO:0015928 IEA
    beta-glucanase activity GO:0052736 IEA
    hexosaminidase activity GO:0015929 IEA
    mannosyl-oligosaccharide mannosidase activity GO:0015924 IEA
    lytic transglycosylase activity GO:0008933 IEA
    beta-6-sulfate-N-acetylglucosaminidase activity GO:0052769 IEA
    mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571 IEA
    trehalase activity GO:0015927 IEA
    glucan endo-1,4-beta-glucosidase activity GO:0052859 IEA
    calcium ion binding GO:0005509 IEA
    glycoprotein endo-alpha-1,2-mannosidase activity GO:0004569 IDA
    amylase activity GO:0016160 IEA
    dextrin alpha-glucosidase activity GO:0044653 IEA
    mannosidase activity GO:0015923 IEA
    galactosidase activity GO:0015925 IEA
    hydrolase activity GO:0016787 IEA
    glucosidase activity GO:0015926 IEA
    starch alpha-glucosidase activity GO:0044654 IEA
Biological Process
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA
    glycoprotein catabolic process GO:0006516 IDA
    response to unfolded protein GO:0006986 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum lumen GO:0005788 IDA
 Experiment description of studies that identified Edem3 in exosomes
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Edem3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Edem3 is involved
ER Quality Control Compartment (ERQC) IEA Reactome

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