Gene description for Chmp1b
Gene name charged multivesicular body protein 1B
Gene symbol Chmp1b
Other names/aliases 2810405I11Rik
Chmp1b1
Species Mus musculus
 Database cross references - Chmp1b
ExoCarta ExoCarta_67064
Vesiclepedia VP_67064
Entrez Gene 67064
UniProt Q99LU0  
 Chmp1b identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Chmp1b
Molecular Function
    protein domain specific binding GO:0019904 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    MIT domain binding GO:0090541 IEA
    MIT domain binding GO:0090541 ISO
Biological Process
    plasma membrane repair GO:0001778 ISO
    autophagy GO:0006914 ISO
    nucleus organization GO:0006997 ISO
    mitotic metaphase chromosome alignment GO:0007080 ISO
    regulation of centrosome duplication GO:0010824 IEA
    regulation of centrosome duplication GO:0010824 ISO
    protein transport GO:0015031 IBA
    protein transport GO:0015031 IEA
    nuclear membrane reassembly GO:0031468 ISO
    endosome transport via multivesicular body sorting pathway GO:0032509 IBA
    multivesicular body assembly GO:0036258 NAS
    viral budding via host ESCRT complex GO:0039702 ISO
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 ISO
    establishment of protein localization GO:0045184 ISO
    late endosome to vacuole transport GO:0045324 IBA
    viral budding from plasma membrane GO:0046761 ISO
    cell division GO:0051301 ISO
    vesicle fusion with vacuole GO:0051469 NAS
    multivesicular body-lysosome fusion GO:0061763 NAS
    midbody abscission GO:0061952 ISO
    multivesicular body sorting pathway GO:0071985 ISO
    membrane fission GO:0090148 NAS
    autophagosome maturation GO:0097352 ISO
    regulation of mitotic spindle assembly GO:1901673 ISO
    late endosome to lysosome transport GO:1902774 ISO
Subcellular Localization
    autophagosome membrane GO:0000421 ISO
    kinetochore GO:0000776 ISO
    ESCRT III complex GO:0000815 IBA
    ESCRT III complex GO:0000815 IEA
    ESCRT III complex GO:0000815 ISO
    nuclear pore GO:0005643 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    lysosomal membrane GO:0005765 ISO
    multivesicular body GO:0005771 IBA
    kinetochore microtubule GO:0005828 ISO
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 ISO
    endosome membrane GO:0010008 ISO
    membrane coat GO:0030117 IEA
    membrane coat GO:0030117 ISO
    midbody GO:0030496 ISO
    multivesicular body membrane GO:0032585 ISO
    amphisome membrane GO:1904930 ISO
 Experiment description of studies that identified Chmp1b in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Chmp1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pex11b  
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Uhrf1bp1l  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Chmp1b is involved
No pathways found





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