Gene description for Pnpla8
Gene name patatin-like phospholipase domain containing 8
Gene symbol Pnpla8
Other names/aliases 1200006O19Rik
AI467579
Ipla2(gamma)
Species Mus musculus
 Database cross references - Pnpla8
ExoCarta ExoCarta_67452
Entrez Gene 67452
UniProt Q8K1N1  
 Pnpla8 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Pnpla8
Molecular Function
    hydrolase activity GO:0016787 IEA
    calcium-independent phospholipase A2 activity GO:0047499 ISO
    lysophospholipase activity GO:0004622 IEA
Biological Process
    linoleic acid metabolic process GO:0043651 ISO
    prostaglandin biosynthetic process GO:0001516 ISO
    metabolic process GO:0008152 IEA
    phosphatidylethanolamine catabolic process GO:0046338 ISO
    lipid metabolic process GO:0006629 IEA
    arachidonic acid secretion GO:0050482 ISO
    lipid catabolic process GO:0016042 IEA
    phosphatidylcholine catabolic process GO:0034638 ISO
    cell death GO:0008219 ISO
    arachidonic acid metabolic process GO:0019369 ISO
    fatty acid metabolic process GO:0006631 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    endoplasmic reticulum GO:0005783 IEA
    integral component of membrane GO:0016021 IEA
    peroxisomal membrane GO:0005778 ISO
    membrane GO:0016020 ISO
    peroxisome GO:0005777 ISO
    Golgi apparatus GO:0005794 IEA
    intracellular GO:0005622 ISO
 Experiment description of studies that identified Pnpla8 in exosomes
1
Experiment ID 263
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pnpla8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pnpla8 is involved
PathwayEvidenceSource
Acyl chain remodelling of PC IEA Reactome
Acyl chain remodelling of PE IEA Reactome





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