Gene description for Arpc5
Gene name actin related protein 2/3 complex, subunit 5
Gene symbol Arpc5
Other names/aliases 5830443F10Rik
p16-Arc
Species Mus musculus
 Database cross references - Arpc5
ExoCarta ExoCarta_67771
Entrez Gene 67771
UniProt Q9CPW4  
 Arpc5 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Arpc5
Molecular Function
    actin binding GO:0003779 IEA
    actin filament binding GO:0051015 ISO
    structural constituent of cytoskeleton GO:0005200 ISO
Biological Process
    cell migration GO:0016477 ISO
    Arp2/3 complex-mediated actin nucleation GO:0034314 ISO
    regulation of actin filament polymerization GO:0030833 IEA
Subcellular Localization
    focal adhesion GO:0005925 ISO
    cytoplasm GO:0005737 IEA
    cytoskeleton GO:0005856 IEA
    cell projection GO:0042995 IEA
    Arp2/3 protein complex GO:0005885 TAS
    lamellipodium GO:0030027 IDA
    extracellular exosome GO:0070062 ISO
    actin cytoskeleton GO:0015629 IEA
 Experiment description of studies that identified Arpc5 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Arpc5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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